Phosphatidylinositol-3 kinases activation

Knall C, Worthen GS, Johnson GL. Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases. Proc Natl Acad Sci U S A 1997 94(7) 3052-3057. 

Cheatham, B., Vlahos, C. J., Cheatham, L., Wang, L., Blenis, J., and Kahn, C. R. (1994). Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol. 14, 4902-4911. 

Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C and Fotsis T. 2004. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3 -kinase activity. Cancer Res 64(21) 7936-7946. 

Additional information <1, 2, 3, 4, 38> (<2>, in cells loaded with protein-tyrosine phosphatase antibody, phosphatidylinositol 3 -kinase activity is increased by 38%, respectively, compared with control cells loaded with preim-mune IgG [11] <4>, b2-integrins activate the tyrosine kinases p58c-fgr and p59/61hck and causes them to associate with the p85 subunit of Ptdins 3-... 

S. Phosphatidylinositol-3-kinase activation and atypical protein kinase C z phosphorylation characterize the DMSO signaling in erythroleukemia cells. Cell. Signal., 12, 667-672 (2000)... 

Kirito, K., Watanabe, T., Sawada, K., Endo, H., Ozawa, K., and Komatsu, N. (2002). Thrombo-poietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways. J. Biol Chem. 277, 8329-8337. 

Sharma, P.M., Egawa, K., Huang, Y., Martin, J.L., Huvar, I., Boss, G.R., and Olefsky, J.M., 1998, Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action. J. Biol. Chem. 273 18528-18537. 

Trophic factors exemplified by NGF and its family members, ciliary neurotrophic factor (CNTF) and glial derived neurotrophic factor (GDNF) all utilize increased tyrosine phosphorylation of cellular substrates to mediate neuronal cell survival. Actions of the NGF family of neurotrophins are not only dictated by ras activation through the Trk family of receptor tyrosine kinases, but also a survival pathway defined by phosphatidylinositol-3-kinase activity (Yao and Cooper, 1995), which gives rise to phosphoinositide intermediates that activate the serine/ threonine kinase Akt/PKB (Dudek et al., 1997). Induction of the serine-threonine kinase activity is critical for cell survival, as well as cell proliferation. Hence, for many trophic factors, multiple proteins constitute a functional multisubunit receptor complex that activates rai-depen-dent and ras-independent intracellular signaling. 

Jullien, D. et al., Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity, J. Biol. Chem., 268, 15246, 1993. 

Knall, C., Worthen, G.S. and Johnson, G.L. (1997). Interleukin 8—stimulated phosphatidylinositol-3-kinase activity regulates the migration of human... 

Siegel RM (2006) Caspases at the crossroads of immune-cell life and death. Nat Rev Immunol 6 308-317 Skorski T et al (1995) Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells. Blood 86 726-736... 

Neri, LM, Martelli, AM, Colamusssi, P, Borgatti, P, Marchisio, M and Capitani, S (1999) Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-zeta translocation to the nucleus of NGF-treated PC12 ceUs. FASEB J, 13, 2299-2310. 

Shimoke K, Yamagishi S, Yamada M, Dceuchi T, Hatanaka H. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain Res Dev Brain Res 1999 112(2) 245-253. 

Bagli, E., Stefaniotou, M., Morbidelli, L., Ziche, M., Psillas, K., Murphy, C., and Fotsis, T. 2004. Luteolin inghibits vascular endothelialgrowth factor-induced angiogenesis Inhibition of endothelial cellsurvival and proliferation by targeting phosphatidylinositol 3 -kinase activity . Cancer Res., 64 7936-7946. 

Sanlioglu S, Benson PK, Yang J, Atkinson EM, Reynolds T, Engelhardt JF. Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by racl and phosphatidylinositol-3 kinase activation. J Virol 2000 74 9184-9196. 

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