Effects of Mitogen-Activated Protein Kinases on T Cells

Effects of Mitogen-Activated Protein Kinases on T Cells 

Induction of ERK is important for T-cell activation. The interaction of antigen with TCR in the context of MHC molecules results in the recruitment of various molecules including Grab2 and SLP76, both adaptor proteins to the cell surface. 

This results in induction of the sos-ras-MEK-ERK pathway. The ERK pathway has also been implicated in thymocyte selection and maturation, TH2 differentiation, and IL-4-induced STAT6 and IL-4 receptor phosphorylation. 

Cell Surface Signals Activate Extracellular Signal-Regulated Kinase 1/2 and Other Mitogen-Activated Protein Kinases 

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