Mitogen-activated protein kinase pathway, tumor suppressor activities

In the proper cellular context in B cells, NK cells and mast cells, Syk kinase has been shown to transduce cell growth and survival signals by activating PI3K/Akt and Ras/mitogen-activated protein kinase pathways [3,46]. When deregulated, Syk activity can promote myelodysplasias, leukemogenesis, and perhaps viral-media ted cellular transformations [47,48]. By contrast, Syk has also been proposed to function as a tumor suppressor [49]. This is however, based on... 

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