Growth factor, receptors

C, which is found in complement proteins FI, F2, and F3, first found in fibronectin I, the immunoglobulin superfamily domain N, found in some growth factor receptors E, a module homologous to the calcium-binding E-F hand domain and LB, a lectin module found in some cell surface proteins. (Adapted from Baron, M., Norman, D., and Campbell, I., 1991, Protein modnles. Trends in Biochemical Sciences 16 13—1 7.)... 

VEGF-R1/ VEGF-R2 Growth factor receptors Decrease of in vivo tumor growth decrease of in vivo metastatic ability (VEGF-R2 only)... 

The epidermal growth factor receptor 2 (HER-2) is a protein found on the surface of cells. Heterodimerization of HER-2 activates the enzyme tyrosine kinase, triggering reactions that cause the cells to grow and multiply. HER-2 is found at abnormally high levels on the surface of many types of cancer cells, which may divide excessively. Antibodies targeting HER-2 (e.g., trastuzumab) are used as antineoplastic agents. 

Epidermal Growth Factor Receptor Family Growth Factors... 

Besides the cytokine receptors that lack intrinsic kinase activity but have associated JAK kinases, STAT proteins can be activated by a variety of G-protein coupled receptors and growth factor receptors with intrinsic tyrosine kinase activity (for example EGF, PDGF, CSF-1, and angiotensin receptor). Increasing evidence suggests a critical role for STAT family members in oncogenesis and aberrant cell proliferation. Constitutively activated STATs have been found in many transformed cell lines and a wide variety of human tumor entities. Numerous non-receptor tyrosine kinases and viral oncoproteins, such as v-Src, v-Abl, v-Sis, and v-Eyk, have been identified to induce DNA-binding activity of STAT proteins. 

Ras is a G protein that cycle between two conformations, an activated Ras-GTP or inactivated form Ras-GDP. Ras, attached to the cell membrane by lipidation, is a key component in many signalling cascades, which couple growth factor receptors to downstream effectors that control such processes as cytoskeletal integrity, proliferation, cell adhesion, apoptosis and cell migration. Mutations and dysregulations of the Ras protein leading to increased invasion and metastasis, and decreased apoptosis are very common in cancers. 

Harari PM (2004) Epidermal growth factor receptor inhibition strategies in oncology. Endocr. Relat. Cancer 11 689-708... 

Epidermal Growth Factor (EGF) Receptor Family Epidermal Growth Factor Receptor 2 (ErbB2) Epidural (Space)... 

Platelet-activating Factor Platelet Aggregation Inhibitors Platelet-derived Growth Factor Receptor Platelet Inhibitors Platelets... 

Achondroplasia (MIM 100800) Mutations in the gene encoding the fibroblast growth factor receptor 3... 

THE MOLECULAR BASES OF THE CHONDRODYSPLASIAS INCLUDE MUTATIONS IN GENES ENCODING TYPE II COLLAGEN FIBROBLAST GROWTH FACTOR RECEPTORS... 

Burke D et al Fibroblast growth factor receptors lessons from the genes. Trends Biochem Sci 1998 23 59. 

Mechanism of Palytoxin Action on the Epidermal Growth Factor Receptor... 

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