Cells cycle progression

Estrogen receptor Transcriptional regulator Inhibition of cell-cycle progression... 

Giacinti C, Giordano A (2006) RB and cell cycle progression. Oncogene 25 5220-5227... 

Inhibition of hematopoietic growth factors Imatinib (Glivec ) is applied to treat chronic myeloid leukemia in Philadelphia-chromosome positive patients. In these patients, translocation of parts of chromosomes 9 and 22 results in the expression of a fusion protein with increased tyrosine kinase activity, called Bcr-Abl. Imatinib is a small Mw inhibitor selective for the tyrosine kinase activity of Bcr-Abl. Thereby, it inhibits the Bcr-Abl induced cell cycle progression and the uncontrolled proliferation of tumor cells. 

Othet cyclins and CDKs are involved in different aspects of cell cycle progression (Table 36-7). Cychn E and CDK2 form a complex in late Gl. Cychn E is tapidly degraded, and the released CDK2 then fotms a complex with cyclin A. This sequence is necessaty fot the initiation of DNA synthesis in S phase. A complex between cychn B and CDKl is tate-hmiting fot the G2/M transition in eukatyotic cells. 

Table 36-7. Cyclins and cyclin-dependent kinases involved in cell cycle progression.

The effect of quercetin on cell cycle progression and growth of hiunan gastric cancer cells , Febs Lett, 260, 10-13. 

HASEGAWA T, NisHiNO H and IWASHIMA A (1993) Isothiocyauates inhibit cell cycle progression of HeLa cells at G2/M phase . Anticancer Drugs, 4 273-9. 

MATSUKAWA Y, MARUI N, SAKAI T, SATOMI Y, YOSHIDA M, MATSUMOTO K, NISHINO H, AOIKE A (1993) Genistein arrests cell cycle progression at G2M. Cancer Res. 53 1328-31. 

Karas, M. et ah. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells, Nutr. Cancer, 36,101, 2000. 

Amir, H. et ah. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells, Nutr. Cancer, 33, 105, 1999. 

Krek, W., Marks, J., Schmitz, N Nigg, E. A., and Simanis, V. (1992). Vertebrate p34c 2 phosphorylation site mutants effects upon cell cycle progression in the fission yeast Schizosaccammyces pombe. J. Cell Sci. 102 43-53. 

Giancotti, F. G., Integrin signaling specificity and control of cell survival and cell cycle progression, Curr. Opin. Cell. Biol., 9, 691-700, 1997. 

Hunt Can I paraphrase that question There is a twofold difference in the level of p57 for example, depending on whether it is or isn t imprinted. What difference does this make to cell cycle progression ... 

Edgar I can address the first question concerning the relationship between cell growth and the cell cycle. In all the experiments we have done, we have found that cell cycle progression—especially the DNA replication cycle—is required for growth. This is fairly trivial. 

Raff It may be that the IGFs are mainly stimulating cell growth and only secondarily stimulate cell cycle progression. It could be that most of their effects are on cell growth and cell survival. 

The size of egg cells demonstrates that higher eukaryotes have evolved ways to uncouple cell growth and cell cycle progression. The Drosophila egg is about 10 000-fold larger than the stem cells in the ovary. Much of the egg content is... 

This suggests that cyclin A2 is not essential for the early embryonic cell cycles. Also D-type cyclins seem to be dispensable for the early mouse embryo cell cycle progression since embryonic stem (ES) cells do not express them at all before differentiation (Savatier et al 1996). We do not know, however, whether the D-type cyclins are also absent in the early embryo. These observations suggest that not only could the first cell cycles of the mouse embryo have specific modifications, but also further embryonic cell cycles are specifically modified as well. Mammalian embryonic cell cycles are probably modified often during development. Such studies could allow us to determine a profile of a minimal cell cycle in mammals which must, however, be much more complex than a simple S M phase embryonic cell cycle of amphibians or insects. 

Raff Many of these experiments that suggest that cells have a size threshold are done in culture, with saturating amounts of extracellular signals that stimulate cell growth and cell cycle progression. In these conditions, cells will tend to be the same size, but these signals are not saturating in vivo. 

Hong Y, Roy R, Ambros V 1998 Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegant. Development 125 3585—3597... 

Gorbsky GJ 1994 Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(+)-l,2-bis(3,5-dioxopiperazinyl-l-yl)propane ADR-529] and ICRF-159 (Razoxane). Cancer Res 54 1042-1048... 

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