Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Excipient

Excimer lamp Excimer laser Excipients Excitation spectrum Exclamation Exclusion chart Exelderm Exelgyn... [Pg.387]

Handbook of Pharmaceutical Excipients American Pharmaceutical Association/The Pharmaceutical Society of Great Britain, Washington, D.C. and London, 1986, pp. 19, 99, 101, 145, 240, 333. [Pg.351]

Eorensic science laboratories may have different missions and therefore conduct different types of testing on samples (21,22). Eor example, the United States Department of Justice, Dmg Enforcement Administration (DEA) forensic laboratories assist authorities ia criminal intelligence-gathering efforts. As such, DEA chemists routinely analyze both the iUicit dmg and excipient, the material used ia the cutting or diluting of the pure dmg, ia a given specimen. The excipient may provide information as to where the sample was produced. [Pg.486]

Local and state forensic laboratories generally do not engage ia excipient testing. Most provide quaUtative and quantitative analysis of the evidence to determine if an Ulegal substance is present and if so, the amount of the dmg present. The quantity of dmg seized by the authorities may be important ia jurisdictions which give enhanced sentences for larger amounts of the pure dmg, or ia some cases the total weight on the dmg and diluent ia possession of the defendant. [Pg.486]

Pigs received daily injections of excipient or the specified dose of recombinant pST. Data are least square means summarized from Refs. 73 and 74. [Pg.411]

The US. Pharmacopeia (USP XXII) or National Formula (NFXVII) (20) also provide a similar description however, the peroxide value is not defined (Table 9). These specifications are also given in the Handbook of Pharmaceutical Excipients (HPE), pubhshed jointiy by the American Pharmaceutical Association and The Pharmaceutical Society of Great Britain (21), which defines lecithins both from plants and eggs. The Merck Index (22) specifies a slightiy lower acid value. The Japanese Monograph (ISCI-II) (23) specifies a slightiy lower acetone-insoluble matter and a lower heavy-metal content. [Pg.103]

Lecithia," Handbook of Pharmaceutical Excipients., American Pharmaceutical Association, Washiagton, D.C., 1986, p. 165. [Pg.105]

The selection of excipient ingredients is important. These must be both chemically and physically compatible with the dmg moiety and cannot negatively affect product stabihty or therapeutic performance, ie, bio avadabihty. A comprehensive hst of various types of excipient ingredients, with comment upon usage, is available (16). [Pg.224]

Bioavailability, Bioequivalence, and Pharmacokinetics. Bioavailabihty can be defined as the amount and rate of absorption of a dmg into the body from an adrninistered dmg product. It is affected by the excipient ingredients in the product, the manufacturing technologies employed, and physical and chemical properties of the dmg itself, eg, particle size and polymorphic form. Two dmg products of the same type, eg, compressed tablets, that contain the same amount of the same dmg are pharmaceutical equivalents, but may have different degrees of bioavailabihty. These are chemical equivalents but are not necessarily bioequivalents. For two pharmaceutically equivalent dmg products to be bioequivalent, they must achieve the same plasma concentration in the same amount of time, ie, have equivalent bioavadabihties. [Pg.227]

Common excipients diluents, disintegrators, binders, and lubricants (gUdants). [Pg.229]

The availabihty of spray-dried lactose, microcrystaUine cellulose, and other excipients allows for the use of granular rather than powdered phases. This eliminates some of the problems of particle segregation according to size (demixing) and even flow to the die. Direct compression eventually may be the preferred method of tablet preparation. [Pg.229]

This technology is relatively expensive to produce. Special excipients and equipment, such as a laser unit to drill the necessary hole for dmg release, are required. However, the achievement of very steady blood levels of a dmg for sustained periods, ie, 2ero-order rate release, of therapy is advantageous. [Pg.232]

Intravenous aqueous injections provide an excellent means of achieving a rapid therapeutic response. Parenteral product design, eg, vehicle and other excipient selection, as well as choice of route of adrninistration, can prolong therapeutic activity and increase onset times. Thus, oily solutions, suspensions, or emulsions can be adrninistered by subcutaneous or intramuscular routes to create prolonged effect, ie, depot injection (28). [Pg.233]

Single-dose preparations intended for use in eye surgery do not contain excipient ingredients, in order to avoid tissue irritation. However, multiple-dose containers may require antioxidants (qv), antimicrobial preservatives, or buffers to maintain stabiHty and stefiHty. Such solutions are packaged in polyethylene flexible dropper units called droptainers or in glass dropper botdes. [Pg.234]

Ophthalmic ointments usually contain petrolatum as the base. The petrolatum is sterilized by dry heat and combined with the sterile dmg powder under aseptic conditions. Ophthalmic suspensions contain very fine (- 10 ji) particle sized soHds suspended in an aqueous vehicle. The vehicle is adjusted to isotonicity and viscosity-increasing excipients, chelating agents, and surfactants also may be needed. The aqueous vehicle in these cases is generally autoclaved and mixed with sterile dmg powder asceptically (30). [Pg.234]

It is also a guideline to ensure product quahty through the suitabihty of the manufacturing equipment, air and water quahty, sanitation, insect and rodent control, and housekeeping. The FDA periodically sends inspectors to audit chemical companies who manufacture bulk pharmaceutical chemicals or inactive ingredients called excipients to ensure conformance. Whereas GMP conformance ensures that the product meets pharmaceutical quahty standards, it does not ensure conformance to customer-service-related requirements. [Pg.372]

Technetium-99m teboroxime is a myocardial imaging agent and is excreted primarily by the hepatobiliary system. It is rapidly taken up by the myocardium and mosdy washes out within 30 minutes. Imaging protocols are performed immediately after injection. The product is a lyopbili ed mixture of boronic acid, dioxine, and other excipients, and the agent is formed with a beating step. [Pg.484]

Papaverine, used to treat heart diseases as a vasodilator, is a dmg that was originally made from vanillin but has since been made from veratrole and (9f2v (9-l,2-dimethoxybenzene. Vanillin is also used as a pharmaceutical excipient. [Pg.400]

E. Barabas and C. Adeyeye, "Crospovidone," Anal Profiles Drug Subst. Excipients, 24, 87—163 (1996). [Pg.535]

Lactose occurs in milk, mainly free, but to a small extent as a component of higher oligosaccharides. Cow and goat milks contain about 4.5% lactose human milk contains about 7.0%. Lactose is used as an excipient in tablets to provide bulk and rapid disintegration. It is also used in some food products where it contributes body with only about 40% the sweetness of sucrose and enhances colors and flavors. [Pg.483]

Material Processing. There are many types of dmg deHvery systems and the manufactuting of each system consists of fabricating a device as weU as loading the dmg and other excipients iato this device. The dmg can be iatroduced iato various components of the system by physical and chemical means, and at various stages of system fabrication (150). [Pg.233]

Perhaps a more specialized case of using plasticizers in acrylic formulations can be found in drug delivery patches. Here, plasticizing additives called excipients... [Pg.504]

The second example is the SE-HPLC analysis of recombinant hGH. In this example, SE-HPLC is used for both a purity and a protein concentration method for bulk and formulated finished products. This method selectively separates both low molecular weight excipient materials and high molecular weight dimer and aggregate forms of hGH from monomeric hGH, as shown... [Pg.533]

H. L. El-Subbagh and A. A. Al-Badr, Anal. Profiles Drug Subst. Excipients 25, 463 (1998). [Pg.336]

Araneimittel, n. medicine, remedy, -kunde, -lehre,/. pharmacology, -tr er, m. (Pharm.) carrier, excipient, menstruum. [Pg.35]

The analysis of a pharmaceutical tablet (6) requires sample preparation that is little more complex as most tablets contain excipients (a solid diluent) that may be starch, chalk, silica gel, cellulose or some other physiologically inert material. This sample preparation procedure depends on the insolubility of the excipient in methanol. As the components of interest are both acidic and neutral, the separation was achieved by exploiting both the ionic interactions between the organic acids and the adsorbed ion exchanger and the dispersive interactions with the remaining exposed reverse phase. [Pg.215]

To remove the excipient, the tablet was ground to a powder and a weighed portion treated with a known volume of a mixture of 5% glacial acetic acid in methanol. The slurry was well stirred to ensure all the active ingredients were dissolved and the mixture was filtered. [Pg.215]

Table 3.3 Common excipients used in the formulation of drug products. Table 3.3 Common excipients used in the formulation of drug products.

See other pages where Excipient is mentioned: [Pg.436]    [Pg.531]    [Pg.532]    [Pg.197]    [Pg.104]    [Pg.224]    [Pg.224]    [Pg.227]    [Pg.229]    [Pg.231]    [Pg.7]    [Pg.54]    [Pg.54]    [Pg.244]    [Pg.238]    [Pg.119]    [Pg.301]    [Pg.308]    [Pg.2064]    [Pg.505]    [Pg.305]    [Pg.54]    [Pg.55]   
See also in sourсe #XX -- [ Pg.54 ]

See also in sourсe #XX -- [ Pg.149 , Pg.310 ]

See also in sourсe #XX -- [ Pg.59 ]

See also in sourсe #XX -- [ Pg.31 , Pg.155 , Pg.202 , Pg.211 , Pg.216 , Pg.348 , Pg.355 , Pg.363 , Pg.365 , Pg.372 , Pg.430 ]

See also in sourсe #XX -- [ Pg.35 ]

See also in sourсe #XX -- [ Pg.35 ]

See also in sourсe #XX -- [ Pg.764 , Pg.1622 , Pg.1656 , Pg.3647 ]

See also in sourсe #XX -- [ Pg.10 ]

See also in sourсe #XX -- [ Pg.63 , Pg.64 , Pg.65 ]

See also in sourсe #XX -- [ Pg.119 , Pg.131 , Pg.133 , Pg.134 , Pg.274 , Pg.275 , Pg.276 , Pg.277 ]

See also in sourсe #XX -- [ Pg.406 ]

See also in sourсe #XX -- [ Pg.86 , Pg.87 , Pg.140 , Pg.141 , Pg.144 , Pg.147 , Pg.154 , Pg.155 , Pg.160 , Pg.174 , Pg.275 , Pg.276 , Pg.277 , Pg.278 , Pg.282 , Pg.283 , Pg.289 ]

See also in sourсe #XX -- [ Pg.173 , Pg.339 , Pg.749 ]

See also in sourсe #XX -- [ Pg.925 , Pg.966 ]




SEARCH



Accuracy excipients

Active ingredients and excipients

Active pharmaceutical ingredient and excipients

Active pharmaceutical ingredients excipient interactions

Active pharmaceutical interaction with excipients

Additives in Excipients

Adverse reactions excipients

Amorphous excipient

Amorphous excipients

Applications as a Pharmaceutical Excipient

Applications, pharmaceutical excipients

Auxiliary excipients

Bioavailability pharmaceutical excipients

Brittle excipient

Bulk pharmaceutical excipients

Carbohydrate excipients

Carbohydrate excipients lactose

Chelating agents excipients

Chemical stability interaction with excipients

Chiral excipients

Clays, excipients

Co-processed excipients

Compaction physics excipients

Compatibility drug/excipient interactions

Compatibility of Excipients with API(s) (Type and Ratio)

Compressible tablet excipients, lactose

Compressible tablet excipients, lactose spray dried

Controlled release systems polymeric excipients

Defined excipients

Degradation excipient

Differential scanning calorimetry excipient compatibility study

Drug administration excipients

Drug and Excipient

Drug design excipients

Drug products, formulation development excipient selection

Drug substances excipient compatibility studies

Drug substances excipients and

Drug-delivery systems control excipients

Drug-excipient compatibility

Drug-excipient compatibility experimental design

Drug-excipient compatibility studies

Drug-excipient interaction

Drug-excipient interactions amorphous product

Drug-excipient interactions crystalline

Drug-excipient miscibility

Drugs and excipients

Ductile excipient

Effervescent excipients

Effervescent formulation excipients

Emerging Excipients in Parenteral Medications The New Paradigm

Estimation of Excipient Percolation Threshold

Ethanol excipient

Excipient Absorbance background

Excipient Auditing

Excipient Binder

Excipient Classification

Excipient Compactibility

Excipient Control strategy

Excipient Development Stagnation

Excipient E Numbers

Excipient EINECS Numbers

Excipient Filler

Excipient Functionality

Excipient Functionality by Coprocessing

Excipient Functionality testing

Excipient Impurities

Excipient Interactions

Excipient Library

Excipient Material properties

Excipient Mediated Photochemistry

Excipient Molecular Weights

Excipient Particle size

Excipient Physical property

Excipient Quality Assurance Handling, Sampling, and Regulatory Issues

Excipient Quality system

Excipient Regulatory status

Excipient Selection

Excipient Selection and Criteria for Injectable Dosage Forms

Excipient absorption

Excipient active ingredients

Excipient additives

Excipient adverse effects

Excipient antimicrobial

Excipient antioxidants

Excipient application

Excipient approval mechanics

Excipient aqueous-based solubilized

Excipient benzyl alcohol

Excipient bile acids

Excipient bioburden

Excipient bulk density

Excipient bulking agents

Excipient capsule formulation

Excipient category

Excipient cellulose derivatives used

Excipient celluloses

Excipient changes

Excipient changes studies

Excipient characteristics

Excipient chelating agents

Excipient chemical properties

Excipient chemical shifts

Excipient chemical stability

Excipient classes

Excipient compatibility

Excipient compatibility analysis using isothermal calorimetry

Excipient compatibility example

Excipient compatibility screening using DSC

Excipient compatibility studies

Excipient compatibility with APIs

Excipient concentration

Excipient construction

Excipient controlled-released solid dosage forms

Excipient cosmetics

Excipient crystal morphology

Excipient crystalline

Excipient crystallization

Excipient definition

Excipient distribution

Excipient drug carrier system

Excipient drug delivery system

Excipient drug targeting

Excipient effects

Excipient efficacy

Excipient emulsifying agents

Excipient encapsulation efficiency

Excipient excretion

Excipient fermentation processes

Excipient fine particle fraction

Excipient flowability

Excipient food additive petition

Excipient formulation

Excipient function

Excipient functionality tests

Excipient gelatin capsules

Excipient harmonization

Excipient hydroxypropyl methylcellulose

Excipient hygroscopicity

Excipient impurity profile

Excipient in drug product

Excipient ingredients

Excipient injectable formulations

Excipient interaction with

Excipient lactose

Excipient liquid

Excipient literature

Excipient magnesium stearate

Excipient manufacturability

Excipient materials

Excipient measurement

Excipient mechanisms

Excipient metabolism

Excipient metal complexing

Excipient microemulsion

Excipient microencapsulation

Excipient moisture content

Excipient moisture level

Excipient oral formulations

Excipient osmotic agents

Excipient paint thickeners

Excipient parabens

Excipient pharmaceutical

Excipient pharmaceutical inhalation aerosols

Excipient phospholipid-based

Excipient physical stability

Excipient poly polymers

Excipient polyethylene glycols

Excipient polyethylene glycols excipients

Excipient polymeric excipients

Excipient polymorphic forms

Excipient powder aerosol formulations

Excipient powder formulation

Excipient powders

Excipient preservatives

Excipient process

Excipient process AIDS

Excipient profile addresses

Excipient properties

Excipient protectants

Excipient reducing agents

Excipient safety testing protocol

Excipient specification

Excipient standards, drug

Excipient starch derivatives used

Excipient starches

Excipient sugars

Excipient surfactant excipients

Excipient surfactants

Excipient thermal analyses

Excipient water-soluble organic solvents

Excipient, acacia

Excipient, examples

Excipient-Drug Conjugates

Excipient-related toxicity

Excipients

Excipients

Excipients Fiedler encyclopedia

Excipients Used in Oral Liquid Formulations

Excipients Used in Site-Specific-Release Formulations

Excipients Used in Sustained Release Formulations

Excipients Used in Vaccines

Excipients additives

Excipients animal derived

Excipients antimicrobial effect

Excipients approved

Excipients attributes

Excipients biological products

Excipients buffers

Excipients characteristics

Excipients children

Excipients classification

Excipients colouring agents

Excipients compatibility

Excipients compatibility, drug products

Excipients control

Excipients criteria

Excipients definitions

Excipients devitrification

Excipients drug compatibility

Excipients effect

Excipients for Delivery of Water-Insoluble Agents

Excipients for Injectable Formulations

Excipients for Oral Liquid Formulations

Excipients for Over-the-Counter Drugs

Excipients for Protein Drugs

Excipients for Pulmonary Formulations

Excipients for Semisolid Formulations

Excipients formulation development

Excipients frequently used

Excipients functionality-related characteristics

Excipients functions

Excipients glassy

Excipients importation

Excipients in New Drugs

Excipients in pharmaceuticals

Excipients in tablets and capsules

Excipients information

Excipients interaction with

Excipients labelling

Excipients liquid dosage forms

Excipients liquid drug formulations

Excipients liquid formulations

Excipients medication interactions

Excipients microbial limits

Excipients moisture

Excipients moisture content

Excipients of Human or Animal Origin

Excipients parenteral formulations

Excipients patent protection

Excipients peptides

Excipients permeation enhancers

Excipients peroxide impurities

Excipients phamaceutical

Excipients physicochemical characteristics

Excipients polymeric

Excipients polymers

Excipients polyvinyl pyrrolidone

Excipients preformulation studies

Excipients preservatives

Excipients probe stability

Excipients product interaction

Excipients properties

Excipients regulatory requirements

Excipients risk assessment

Excipients safety

Excipients selection

Excipients solid drug products

Excipients solid drug stability

Excipients solvent extraction methods

Excipients stability

Excipients starch

Excipients storage

Excipients structure-forming

Excipients sweetening agents

Excipients tablets

Excipients tabletting

Excipients typical

Excipients volatile

Excipients water content

Excipients, drug complexation with

Excipients, injectable products

Excipients, lyophilized formulations

Excipients, novel

Eyedrops excipients

Factors Affecting Excipient Absorbance Background

Fiedler encyclopedia of excipients

Final product formulations stabilizing excipients

Food and Drug Administration Excipient Guidance

Formulation development Excipient compatibility screening

Formulations critical excipients

Formulations drug/excipient interactions

Freeze-drying excipient

Freeze-drying excipients

Functional excipients

Good manufacturing practices guide pharmaceutical excipients

Handbook of Pharmaceutical Excipients

Harmonization excipients

Hydrophilic excipients

Hydroxypropylmethylcellulose, excipient

Hypersensitivity/allergic reactions excipients

Imports/importers excipients

Influence of Excipients

Inorganic materials pharmaceutical excipient

Intermediates of synthesis, DS and excipients

International Pharmaceutical Excipient

International Pharmaceutical Excipient Council

International Pharmaceutical Excipient chemical excipients

International Pharmaceutical Excipients

International Pharmaceutical Excipients Council

Isothermal calorimetry (excipient

Japan Pharmaceutical Excipients Council

Japanese Pharmaceutical Excipients

Japanese Pharmaceutical Excipients Directory

Japanese Pharmaceutical Excipients official

Joint Pharmacopeial Open Conference on International Harmonization of Excipient Standards

Labelling excipient composition

Linearity excipients

Liquid drug products, excipients used

Lozenges excipients

Lyophilization excipient

Medications excipients

Microcrystalline cellulose excipients

Microcrystalline cellulose pharmaceutical excipient

Microspheres pharmaceutical excipients

Mineral excipients

Moisture with hydrophilic excipient

Monographs for excipients

Natural Polysaccharides as Pharmaceutical Excipients

Neonates excipients

New Excipients

New Vaccine Adjuvants and Other Excipients

No Independent Status for Excipients

Ointments, excipients

Orally disintegrating tablets excipient

Other Properties of Excipients

Packaging drug-excipient interactions

Particle Engineering for Developing New Excipients

Permeability-Enhancing Excipients

Pharmaceutical Excipient Distributor Strengths

Pharmaceutical excipients

Pharmaceutical excipients, handbook

Pharmaceutical products excipients

Pharmaceuticals process validation excipients

Physical stability excipients

Physicochemical Attributes of Pharmaceutical Excipients

Polymeric Excipients for Controlled Release Applications

Polymers as Formulation Excipients for Hot-Melt Extrusion Processing of Pharmaceuticals

Polysiloxanes as Excipients

Precision excipients

Preclinical Testing for a New Excipient

Preclinical Testing for an Essentially New Excipient

Preclinical Testing for an Established Excipient

Preformulation stage excipient compatibility

Preformulation studies excipient compatibility

Presence of Excipients

Product design drug/excipient interactions

Product optimisation excipient selection

Profiles of Drug Substances, Excipients and Related

Profiles of Drug Substances, Excipients and Related Methodology

Properties of Coprocessed Excipients

Properties of Excipients

Protein/excipient system

Raw materials (intermediates, DS, excipients)

Recovery excipients

Regulation of Pharmaceutical Excipients

Regulatory Aspects of Excipient Quality Assurance

Regulatory Issues of Pharmaceutical Excipients

Regulatory Status and Excipient Quality

Selection of Excipients for Next Generation Vaccines

Sodium carboxymethylcellulose, excipient

Solid dispersions excipients

Solid drug products, excipients used

Solid pharmaceutical dosage forms excipients

Sources of New Excipients

Specificity excipients

Stabilizing excipients used in final product formulations

Storage amorphous sugar excipients

Studies of Tablets and Excipients

Substance and Excipient Characterization

Sucrose pharmaceutical excipient

Tablet excipients, functional

Tablet manufacture excipients

Tablets and capsules, excipients

The Cost to Develop a New Excipient

The Need for Excipients

Tocopherols excipient

Use of Excipient Library

Use of Nonactive Pharmaceutical Excipients in Oral Drug Formulations Biopharmaceutical Classification System Considerations

Vaccines excipients

Validation excipients

Water excipients with

© 2024 chempedia.info