Excipient, acacia

Figure 14.3 Chromatograms of excipients in film-former class under different mobile phase pH. In both plots, the curves from the bottom are blank, HPMC, acacia, sucrose NF, HPC, povidone and Eudragit EPO, respectively. The sample solvent, mobile phase and column used are (a) 20% ACN-80% pH 2, 25 mM phosphate buffer, a gradient from 30% ACN-70% pH 2, 25 mM phosphate buffer to 80% ACN-20% pH 2, 25 mM phosphate buffer and a Zorbax SB-C8, 4.6 x 150 mm, 3.5 p.m column at 35°C, respectively and (b) 20% ACN-80% pH 7, 25 mM phosphate buffer, a gradient from 30% ACN-70% pH 7, 25 mM phosphate buffer to 80% ACN-20% pH 7, 25 mM phosphate buffer and a Zorbax XDB-Cg, 4.6 x 150 mm, 3.5 p,m column at 35°C, respectively. In both cases, samples were injected at 1800 p,L, the flow rate of mobile phase was 1 mL/min and the detection was at 210 nm. An on-bench examination of the mixture of either 80% ACN-20% pH 2, 25 mM phosphate buffer or 80% ACN-20% pH 7, 25 mM phosphate buffer revealed no precipitation, so they were suitable as the mobile phase.

Scheindlin S. Acacia - a remarkable excipient the past, present, and future of gum arabic. JAMA 2001 41(5) 669-671. 

Gum acacia and tragacanth are used in tablets, suppositories, vaginal jellies, and diabetic foods as excipients. A few cases of asthma have been reported to such vegetable gums (Gelfand 1943). Brown and Crepea (1947) reported a patient who was sensitive to tablets containing 0.005 mg tragacanth. 

Glyceryl di/tristearate excipient, tablets Acacia Agar Dextrates Glyceryl pal mitate/stearate Hyd roxypropyl methylcellulose Sucrose polystearate excipient, veterinary medicine Sulfanilamide excipient, veterinary preps. 

The effects of common excipients and other foreign ions were checked under the optimized conditions containing a standard solution of 0.2 Xg/mL of vitamin E. No interference was observed at 250-fold for glycerol, Na+, K+, Ca, Mg +, Zn +, NHJ, S04", PO ", NO3, HCO3, Cl, methylcellulose, cholesterol, stearic acid, sucrose, glucose, starch, gum acacia, magnesium stearate at 100-fold for vitamin D, sorbitol, mannitol, oleic acid, triolein, EPA, DHA, polyvinyl alcohol, albumin, retinyl palmitate at 10-fold... 

Various excipients, such as tragacanth, acacia, starch and dextrin, cause no interference but lactose does, and if this is present the salol must first be extracted by ether. 

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