Lozenges excipients

Mendes, R.W. Anaebonam, A.O. Daruwala, J.B. Chewable tablets. In Pharmaceutical Dosage Forms Tablets, Lieberman, H.A., Lachman, L., Schwartz, J.B., Eds. Marcel Dekker, Inc. New York, 1989 I, 362-387. Richards, R.M. Xing, J.Z. Mackay, K.M. Excipient interaction with cetylpyridinium chloride activity in tablet based lozenges. Pharm. Res. 1996, 13 (8), 1258-1264. 

Mannitol is an isomer of sorbitol. Like the latter, it has a negative heat of solution which makes it a useful excipient for chewable tablets and lozenges. It is less hygroscopic than sorbitol and has about one-tenth of the solubility in water. Similarly to sorbitol, several polymorphic forms are available which differ in their ability to form tablets. " However, unmodified mannitol cannot be used for direct compression because of poor flow and binding properties. Directly compressible forms are available in a range of particle sizes which are reported to produce excellent tablets. 

Richards RM, Xing JZ, Mackay KM. Excipient interaction with cetylpyridinium chloride activity in tablet based lozenges. Pharm Res 2003 13(8) 1258-1264. 

Erythritol is a noncariogenic excipient used in a variety of pharmaceutical preparations, including in solid dosage forms as a tablet filler,and in coatings.It is also used in sugar-free lozenges, " and medicated chewing gum. ... 

Uses Excipient for controlled-release pharmaceutical applies., enteric coatings, coatings resist, to tropical conditions, lozenges, sealing coats Properties Powd. sol. in intestinal fluid from pH 6 flash pt. 13.5 C 12.5%... 

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