Excipients for Pulmonary Formulations

Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, U.S.A. 

Requirement of tightly controlled particle size range for administration to the lungs (1-5 pm) 

Intimately related to these factors is the design of the device, formulation, and the interface with the patient. Much of the discussion below will focus on the implications of excipients on formulation challenges for inhaled aerosol products. This chapter summarizes excipients for pulmonary formulations from several perspectives (i) excipient selection based on principles of delivery, (ii) physicochemical requirements for excipients, and (iii) specific challenges for formulations faced with aerosol drug delivery systems, including (a) biological aspects, (b) microbiological aspects, (c) analytical issues, and (d) future prospects. 

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