Selection of Excipients for Next Generation Vaccines

In conclusion, excipients to be used in vaccines must be very carefully selected and justified to the regulatory authorities because these are to be used in millions of healthy subjects. Their safety and compatibility with other vaccine components are of prime importance. Because vaccines of the future will be more and more complex, the need for suitable excipients is also likely to grow. It must be ensured that the excipients do not compromise the immunogenicity of the vaccine and accord maximum stability upon long-term storage. 

We would like to thank all members of the formulation group in vaccines research for their suggestions and help. 

Vogel FR, Powell MF. A compendium of vaccine adjuvants and excipients. In Powell MF, Newman MJ, eds. Vaccine Design The Subunit and Adjuvant Approach. New York Plenum Press, 1995 141-228. 

Edelman R. Adjuvants for the future. In Levine MM, Woodrow GC, Kaper JB, Cobon GS, eds. New Generation Vaccines. New York Marcel Dekker, Inc., 1997 173-192. 

Gupta RK. Aluminum compounds as vaccine adjuvants. Adv Drug Del Rev 1998 32 155-172. 

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