Isothermal calorimetry excipient

Schmitt E. Excipient compatibility screening by isothermal calorimetry. Fifty-third Calorimetry Conference, Midland, Michigan, U.S.A., 1998. 

Thermal techniques such as isothermal calorimetry (ITC) and differential scanning calorimetry (DSC) have been used in formulation screens to predict the formulation with the greatest stability based on the assumption that excipients that increase the of the protein will stabilize the molecule at the recommended storage temperature. For example, a screen of preservatives performed during formulation development for interleukin-1 receptor found that the for the formulation... 

Excipient compatibility analysis using isothermal calorimetry Microca lo rimetry... 

Chrzanowski FA, Ulissi LA, Fegely BJ, Newman AC. Preformulation excipient compatibility testing, application of a differential scanning calorimetry method versus a wet granulation simulating isothermal stress method. Drug Dev Ind Pharm 1986 12 783-800. 

Microcalorimetry is an extremely sensitive technique that determines the heat emitted or adsorbed by a sample in a variety of processes. Microcalorimetry can be used to characterize pharmaceutical solids to obtain heats of solution, heats of crystallization, heats of reaction, heats of dilution, and heats of adsorption. Isothermal microcalorimetry has been used to investigate drug-excipient compatibility [82]. Pikal and co-workers have used isothermal microcalorimetry to investigate the enthalpy of relaxation in amorphous material [83]. Isothermal microcalorimetry is useful in determining even small amounts of amorphous content in a sample [84]. Solution calorimetry has also been used to quantitate the crystallinity of a sample [85]. Other aspects of isothermal microcalorimetry may be obtained from a review by Buckton [86]. 

---