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Excipient emulsifying agents

Additives are all formulation constituents other than the active ingredient. Although additives could be classified into excipients and vehicles (excipients for solid preparations and vehicles for liquid ones), there are several other agents used in pharmaceutical formulations with specific functions such as preservatives, sweeteners, coatings, colorants, antioxidants, surfactants, emulsifying agents, and flavors. Since they comprise a vast amount of products, this section will deal with additives for compounding pharmaceutical products for internal use only [17,18]. [Pg.467]

Polysaccharides such as starch and vegetable gums have important pharmaceutical uses as excipients, binding agents for tablets, emulsifying agents and demulcents. Dextran finds employment as a plasma extender to maintain the osmotic pressure of blood. [Pg.152]

Buffers can also be provided in parenteral formulations to ensure the required pH needed for solubility and/or stability considerations. Other excipients included in parenteral products are preservatives (e.g., benzyl alcohol, p-hydroxybenzoate esters, and phenol), antioxidants (e.g., ascorbic acid, sodium bisulfite, sodium metabisulfite, cysteine, and butyl hydroxy anisole), surfactants (e.g., polyoxyethylene sorbitan monooleate), and emulsifying agents (e.g., polysorbates). An inert gas (such as nitrogen) can also be used to enhance drug stability. Stability and solubility can also be enhanced by the addition of complexation and chelating agents such as the ethylenediaminetetraacetic acid salts. For a more detailed list of approved excipients in parenteral products, the reader should consult the monographs within the USP. [Pg.1006]

Several phospholipid-based excipients are finding increased application as solubilizing agents, emulsifying agents, or as components of liposomal formulation. The phospholipids occur naturally and are biocompatible and biodegradable. Examples include egg phosphatidylcholine, soybean phosphatidylcholine, hydrogenated soybean phosphatidylcholine (HSPC),... [Pg.1643]

Section 6, Functional Category, lists the function(s) that an excipient is generally thought to perform, e.g., diluent, emulsifying agent, etc. [Pg.940]

Trace chain Chain used to fasten a horse s collar to the whlppletree. Tragacenth A gum obtained from Astragalus gummifer. It comes in thin, white translucent pieces, or flekes. The gum swells up in water and is used in the arts and as an emulsifying agent and excipient in pharmacy. [Pg.22]

Formuia CH3(CH2)2oCO(OCH2CH2)nOH, avg. n = 8 Uses Emulsifier in cosmetics tableting aid in pharmaceuticals PEG-20 behenate Synonyms POE (20) behenate Uses Excipient, coating agent, emulsifier, solubilizer, and wetting agent for pharmaceuticals... [Pg.3071]

The active ingredients or excipients included in cosmetic formulations have different functions (e.g., antioxidants, surfactants or emulsifying agents, preservatives). [Pg.804]

Hydrophilic creams are preferably formulated with combinations of emulsifying agents (mixed layer emulsifying agents or emulsifying agent complexes, see Sect. 18.4.3). For examples of o/w surfactants see Sect. 12.5.4. Generally hydrophilic creams may be anionic-active or non-ionic-active. Because of incompatibilities of active substances with anionic or non-ionic-active surfactants mixtures of these types of emulsiflers have to be avoided. The lipophilic excipients improve the consistency of the cream. These may be hydrocarbons such as white soft paraffin or waxes such as decyl oleate. [Pg.256]

The most important excipients in parenteral nutrition solutions are emulsifying agents. Lecithin and phosphatides are mostly used. The emulsifying capacity of phosphatides correlates with their ionisation rate and thereby the pH of the emulsion. The pH also influences the stability of the hpid droplets [58]. If the pH decreases below 3, the droplet surfaces are no longer negatively charged and the droplets coalesce (see Sect. 18.4.1). If necessary, the pH is adjusted with an aqueous solution of sodium hydroxide or hydrochloric acid. [Pg.289]

Uses Excipient, emulsifier, solubilizer, release agent, bioavailability enhancer for pharmaceuticals Trade Names Gelucire 44/14 PEG (32) glyceryl laurate. See PEG-32 glyceryl laurate PEG-40 glyceryl laurate CAS 59070-56-3 (generic) 51248-32-9 (generic)... [Pg.2294]

Various excipients, gelling agents and emulsifiers for ointments and suppositories stomach dressings appetite suppressant precision castings in dentist ... [Pg.492]


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See also in sourсe #XX -- [ Pg.1624 ]




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