Excipient controlled-released solid dosage forms

EXCIPIENTS IN CONTROLLED RELEASE SOLID DOSAGE FORMS... 

Another example of an excipient-excipient interaction that can be used to our advantage is the one between xanthan gum and locust bean gum (carob gum or cer-atonia) in the presence of water. This interaction forms the basis of the identification test for Xanthan Gum NF. The interaction creates a much more viscous gel system than can be created using either component alone. This has been used in the formulation of controlled release oral solid dosage forms in the TimeRx drug delivery system (11). 

Although excipients are the non-active ingredients, they are indispensable for the successful production of acceptable solid dosage forms. The important roles played by excipients in tablets and capsules, freeze-dried, and spray-dried powders, as well as powder aerosol formulations, were discussed. Some recent applications of excipients in controlled, release formulations for biologicals were also highlighted. Finally, incompatibility problems attributable to excipients were considered with an emphasis on the indirect role of excipients through moisture distribution. 

Uses Pharmaceutical excipient, film-former for enteric coating of solid oral dosage forms, esp. for controlled release of drugs masks unpleasant tastes and odors barrier between incompat. active substances moisture barrier protecting against atmospheric humidity Features Effective barrier to gastric juice protects acid-sensitive drugs releases active at site of action... 

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