Intermediates of synthesis, DS and excipients

Raw materials are now produced by the chemical industry and involve the use of solvents at different steps in their production. These materials are usually produced by  

The goal of this chapter is, of course, not to deal with the criteria for selection in relationship to their use in particular chemical reactions or extraction processes but rather to stress that impurities present in solvents could have an impact on the purity of the substances obtained, on their stability and potentially on their safety. These three concepts are of paramount importance in the pharmaceutical field. 

A list of solvents which are commonly used in the chemical industry is presented in Table 14.21.1.1. 

Methyl ethyl ketone Methyl isobutyl ketone Methyl isopropyl ketraie Mesityl oxide 

Halogenated solvents Ethylene bromide Chloroform Ethylene chloride Dichloromethane Tetrachloroethylene Carbrm tetrachloride Trichloroethylene 

Amine Tert-butyl methyl ether (MTBE) 

It is generally relatively easy to know for pharmaceutical industry the nature of solvents to be looked for in a DS because it produces itself the active component or because it 

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