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Differential scanning calorimetry excipient compatibility study

It was recognized quite some time ago that DTA analysis could be used to deduce the compatibility between a drug substance and its excipients in a formulation. The effect of lubricants on performance was as problematic then as it is now, and DTA proved to be a powerful method in the evaluation of possible incompatibilities. Jacobson and Reier used DTA to study the interaction between various penicillins and stearic acid [17]. For instance, the addition of 5% stearic acid to sodium oxacillin monohydrate completely obliterated the thermal events associated with the antibiotic. Since that time, many workers employed DTA analysis in the study of drug-excipient interactions, although the DTA method has been largely replaced by differential scanning calorimetry technology. [Pg.230]

Botha SA, Lotter AP. Compatibility study between Naproxen and tablet excipients using differential scanning calorimetry. Drug Dev Ind Pharm 1990 16(4) 673-683. [Pg.107]

Holgado, M. A., M. Fernandez-Arevalo, J. M. Gines, I. Caraballo, and A. M. Rabasco. 1995. Compatibility study between carteolol hydrochloride and tablet excipients using differential scanning calorimetry and hot stage microscopy. Pharmazie 50 195-198. [Pg.231]

Botha SA, hotter AP. Compatibility Study Between Atenolol and Tablet Excipients Using Differential Scanning Calorimetry. Drug Dev Ind Pharm 1990 16 673-683. [Pg.329]


See other pages where Differential scanning calorimetry excipient compatibility study is mentioned: [Pg.421]    [Pg.898]    [Pg.597]    [Pg.2724]   


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