Excipient lactose

Experience gained by harmonizing the first of the excipients. Lactose and Magnesium Stearate showed that because so many parties are affected and many expert groups must be convened, forward, retrospective harmonization is intrinsically a lengthy process. 

The wetting behavior of powders is an also important factor for drug dissolution. If the wetting is not satisfactory, hydrophilic excipients (lactose) and surfactant (sodium lauryl sulfate or polysorbate) are combined in the powder mixtures. The contact angle is used as an index of wetting. The lower the contact angle, the better the wetting occurs. 

Dry powder aerosols must begin as a reservoir of free-flowing powder that can be dispersed in the airstream of the patient s inspiratory breath. To achieve a free-flowing powder, an excipient, lactose, is added as a carrier for the drug particles [190,191]. 

Excipients MCC, Aerosil, Lac tos e C rospovidone, andCCS Excipients PEG derivatives, Polyox-40 Castor Oil, and NatiualWaxes Excipients Lactose, Methyl cellulose, MCC, HPMC, CCS and Crospovidone... 

Chitosan (molecular weight, 19-400 kDa degree of deacetylation, 75-98%) has been evaluated as a directly compressible vehicle for tablets, but has found limited utility due to the lack of good flow properties and compressibility. The influence of excipient (lactose, sodium lauryl sulfate, sodium alginate, hydroxypropyl methyl... 

Due to the absence of water, which catalyses many chemical reactions, chemical incompatibilities rarely occur in dry dosage forms. One exception is the incompatibility of the excipient lactose with primary amines, such as amphetamine and lisinopril. The rate of the reaction (Maillard reaction) is slow in absence of water, but may lead to yellow discolouration during storage [25]. 

The size distribution of granules prepared from three different tablet excipients, lactose, glucose, and mannitol, in a high-shear granulator, were studied by both sieve analysis and laser light diffractometry (24). Both the shapes and the size distribution of the granules produced from the three excipients differed. 

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