Excipient phospholipid-based

Several phospholipid-based excipients are finding increased application as solubilizing agents, emulsifying agents, or as components of liposomal formulation. The phospholipids occur naturally and are biocompatible and biodegradable. Examples include egg phosphatidylcholine, soybean phosphatidylcholine, hydrogenated soybean phosphatidylcholine (HSPC),... 

Fluorinated surfactants (or fluorosurfactants, i.e., surfactants with hydrophobic tails comprising a fluorocarbon moiety) provide an alternative means of achieving extremely stable PFC emulsions, as they can provide very low PFC/water interfacial tensions [cr , another factor in Eq. (2)]. d s yet, this option has not been developed, in part because of the added cost involved in the evaluation for approval of a novel active excipient. A further means of effectively increasing the stability of EYP-based PFC emulsion consists of supplementing standard phospholipids with mixed fluorocarbon-hydrocarbon diblock compounds, such as 14 or 15. Such diblocks, which have fluorophilic-lipophilic amphiphilic properties, are expected to improve the adhesion of the phospholipid film onto the PFC droplet. 

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