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Drug-delivery systems control excipients

Another example of an excipient-excipient interaction that can be used to our advantage is the one between xanthan gum and locust bean gum (carob gum or cer-atonia) in the presence of water. This interaction forms the basis of the identification test for Xanthan Gum NF. The interaction creates a much more viscous gel system than can be created using either component alone. This has been used in the formulation of controlled release oral solid dosage forms in the TimeRx drug delivery system (11). [Pg.98]

Factors affecting the delivery include the physical form of the drug, the entry into the body, the design and the formula of the product. This may depend on the physicochemical properties of the excipients, the control of the drug-excipient interaction at the absorption site. Thus, polysaccharides may play an essential role for effectiveness and reliability of the different drug delivery systems. [Pg.3]

FIGURE 22.15 Pharmacokinetic parameters for the Spherazole CR tablet, 100 mg, compared with the Sporanc IR capsule. (Note Types A and B differed in levels of rate-controlling excipients.) (Adapted from Jacob, J. Gastroretentive, bioadhesive drug delivery system for controlled release of itraconazole pharmacokinetics of Spherazole CR in healthy human volunteers. Controlled Release Society 34th Annual Meeting and... [Pg.631]

Peanut oil is used as an excipient in pharmaceutical formulations primarily as a solvent for sustained-release intramuscular injections. It is also used as a vehicle for topical preparations and as a solvent for vitamins and hormones. In addition, it has been part of sustained-release bead formulations, nasal drug delivery systems, and controlled-release injectables. ... [Pg.505]

F. Alvarez-Mancenido, M. Landin, I. Lacik, and R. Martinez-Pacheco, Konjac glucomannan and konjac glucomannan/xanthan gum mixtures as excipients for controlled drug delivery systems. Diffusion of small drugs, Int. J. Pharm., 349 (1), 11-18, 2008. [Pg.363]

K. Reddy, G.K. Mohan, S. Satla and S. Gaikwad, Natural polysaccharides Versatile excipients for controlled drug delivery systems, Nat. Polysaccharides/Asian J. Pharm. ScL, 6 275-286, 2011. [Pg.18]

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See also in sourсe #XX -- [ Pg.999 ]



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