Excipient water-soluble organic solvents

The range of complexity of solubilized oral formulations filled into a capsule varies from a simple one-excipient formulation such as PEG 400 or a long-chain triglyceride, to complex microemulsion preconcentrates which contain oil, cosolvent, and surfactant excipients. The preferred water-soluble organic solvents... 

This is a partially 0-mcthylated and partly O-(hydroxyethylated) cellulose. It is in.soluble in hot water and organic solvents but dissolves in cold water. It is used as an excipient in a wide range of pharmaceutical formulations mainly as a coating for solid dosage forms and granules and as a su.spending agent for disperse systems (a. 13). 

Phase separation microencapsulation procedures are suitable for entrapping water-soluble agents in lactide/glycolide excipients. Generally, the phase separation process involves coacervation of the polymer from an organic solvent by addition of a nonsolvent such as silicone oil. This process has proven useful for microencapsulation of water-soluble peptides and macromolecules (48). 

It is a white crystalline solid, slightly soluble in water, but soluble in acidic aqueous solutions and soluble in organic solvents, such as chloroform and diethyl ether. It is available in the illicit market as hydrochloride salt or free base (crack). Cocaine is usually mixed with other substances used as excipients. 

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