Excipient drug targeting

Drug targeting throughout the GIT has traditionally been accomplished, with variable success, using approaches based on standard pharmaceutical excipients. This approach can... 

The liposomal encapsulation technology is focused on cosmetic and pharmaceutical systems, since the PC fractions are quite costly. Plant scale produced PC phospholipids are used as excipients for targeted drugs transport, encapsulation and cell membrane passage. 

Once preformulation screening has identified which excipients are able to stabilize the API, a series of prototype formulations can be developed, which will be more reflective of the targeted quantities of excipients and drugs present in the final... 

The components (active and excipients) in the formulation should have numerical targets which represent the nominal composition of the drug product on which any future changes in the composition of the product are to be based. Allowable changes in the composition should be based on the approved target composition and not on previous Level 1 changes in the composition. 

Suitable excipients to release a drug in a targeted fashion in the colon and... 

A. W. Sarlikiotis, J. Betzing, Chr. Wohlschlegel, and K. H. Bauer, A new in-vitro method for testing colon targeting drug delivery systems or excipients, Pharmacol. Lett. 2 62-65 (1992). 

---