Therapeutic performance

The selection of excipient ingredients is important. These must be both chemically and physically compatible with the dmg moiety and cannot negatively affect product stabihty or therapeutic performance, ie, bio avadabihty. A comprehensive hst of various types of excipient ingredients, with comment upon usage, is available (16). 

Formulation. Compressed tablet formulations contain several types of inert, adjuvant ingredients necessary for proper preparation and therapeutic performance. Tablets designed to be swallowed need diluent, disintegrating, binding (adhesive), and lubricating inert ingredients, whereas... 

The strongly re search-oriented dentifrice market is dominated by a few primary companies. The industry funds efforts to develop products with superior cosmetic and therapeutic performance. The four principal manufacturers of toothpaste worldwide are Procter Gamble, Unilever, Colgate-Palmohve, and Beecham. Numerous smaller companies and private-label houses also exist. 

Can the biological system be overcome with a delivery system to optimize therapeutic performance ... 

Despite the scientific elegance of the antibody-mediated approach to tumour detection/destruc-tion, initial clinical trials proved disappointing. A number of factors contributed to their poor therapeutic performance, particularly against solid tumours. Most such factors relate directly/ indirectly to the fact that the first generation of such drugs utilized whole monoclonal antibody preparations of murine origin. These factors include ... 

As it is often very difficult to quantify therapeutic performance with pharmacodynamic and clinical studies, pharmacokinetic studies are usually the most suitable tool to describe the performance of the drug product in vivo. Once a relationship between the plasma concentration of the drug or active moiety and the therapeutic effect has been established, BA may be considered to be the perfect surrogate parameter for efficacy and/or safety of a drug product. 

After a new drug has been approved by health authorities and launched in national markets, pharmaceutical companies usually conduct numerous further studies of its therapeutic performance in more extended patient populations. Some typical clinical and scientific goals pursued in Phase IV trials are ... 

In conclusion, both mono-PEGylated interferons present superior properties for protein delivery, resulting in a longer-lasting activity as compared to the native protein, avoiding frequent administration, and improving the therapeutic performance of interferon. 

Compressed tablet formulations contain different types of ingredients necessary for proper preparation and therapeutic performance. The ingredients needed include diluents, disintegrating or binding (adhesive) additives, and lubricants. Tablets are designed to be dissolved slowly in the mouth and should not disintegrate quickly. Lactose... 

Some direct comparisons of DPI and MDI for the same drug have been made in the interest of developing alternative but comparable products for patients. The therapeutic performance of inhalation delivery systems is as dependent on the patient as it is on the product itself. Therefore, some demonstration of clinical comparability is generally required to support product substitution. 

The therapeutic performance of a pharmaceutical dosage form, particularly oral solid dosage forms, which include the majority of drug products... 

Despite the advantages of organogels, it suffers from some limitations or challenges, which mainly affects the stability and therapeutic performance of the organogels. So, many efforts are undertaken in this field to control the same. Some important limitations or drawbacks along with their possible solution of these systems are discussed in the text following ... 

The tricyclic anti-depressants usually have a p of 9.5 to 10 and a partition coefficient of 4 in the system octanol/water. Improvement in their therapeutic performance has followed two directions, both leading to products without effect on the heart. First came the tetracyclic anti-depressants such as mapro-tiline 12.116) and mianserin 12.117). Then there are anti-depressant drugs with much simpler nuclei such as nomifensine 12.118). These newer products... 

Over the last decades, several academic and industrial research programs have been focused on the development and production of appropriate biocompatible formulations that provide enhanced therapeutic performance. Three different strategies can be discerned that are applied separately or in combination (i) addition of excipients to proteins, such as protease inhibitors, penetration or absorption enhancers like bile salts, fatty acids, cyclodextrins or surfactants " (ii) modification of the physicochemical properties of proteins, e.g. by attachment of lipophilic or hydrophilic moieties or (iii) incorporation of proteins into polymeric or liposomal delivery carriers. " A variety of polymeric vectors has been developed and exploited for this purpose, including biodegradable nanoparticles, nanogels, micelles, polymer bioconjugates and soluble nanocomposites. These polymeric carriers are more extensively described in the following sub-sections. 

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