Orally disintegrating tablets excipient

Mishra DN, Bindal M, Singh S-K, Vijaya-Kumar S-G. Spray dried excipient base A novel technique for the formulation of orally disintegrating tablets. Chem Pharm Bull 2006 54 99-102. 

Khinchi MP, Gupta MK, Bhandari A, Sharma N, Agrawal D. Modified polysaccharides as fast disintegrating excipients for orally disintegrating tablets of fexofenadine HCl. Pharm Lett. 3 2) 108-118, 2011. 

Excipients are sub-divided into various functional classifications, depending on the role that they are intended to play in the resultant formulation, for example, fillers, disintegrants, binders, lubricants and glidants. An added complexity is the fact that certain excipients can have different functional roles in different formulation types. Thus, lactose is widely used as a filler or diluent in solid oral dosage forms, for example, tablets and capsules [2] and as a carrier for inhalation products [3]. 

Microcrystalline cellulose - mainly used as a binder or diluent in solid oral dose formulations. It also has lubricant and disintegrant properties which make it a useful excipient in tablet manufacture. 

Multiporous oral drug absorption system. A single-unit, immediate-release tablet formulation consisting of an inner core, containing active drug plus excipients, surrounded by a non-disintegrating, timed release coating. 

Uses Tablet binder/disintegrant, excipient, suspension stabilizer in pharmaceuticals complexing agent detoxifier adsorbent in thin-iayer chromatography clarifier, filter aid, shelf life enhancer in beer, wine Regulatory FDA approved for implants, ophthalmics, orals, injectables, topicals NF, BP, EP compliance... 

It is usually not possible to prepare a capsule, oral powder or tablet from an active substance without the addition of any excipients. Firstly, the volume of the active substance is often very small a diluent is necessary in order to handle the powder mixture. Secondly, the active substance may not have good flow properties these can be improved by addition of a glidant. Another reason to use excipients is that a preparation, consisting only of an active substance, may not disintegrate well in the gastro-intestinal tract a disintegrating agent can improve this. Many excipients combine a number of such functions so the number of different excipients can be limited and the potential interactions between materials can be minimised [12]. The next sections... 

---