Ductile excipient

As shown in Table 6.17, the hardness—compression force profile for Drug A tablets is linear across the range of compression forces studied. This linear profile is attributed to the properties inherent in the brittle and ductile excipients chosen for this formulation. In contrast, the hardness—compression force profile for Drug B shows a plateau in tablet hardness at higher compression forces (> 11 kN), as listed in Table 6.18. 

Table 3 shows that Avicel PH 102 and PH302 formed powder compacts with similar relatively high dynamic indentation hardness, whereas that of Avicel PH 105 was considerably lower, indicating PH 105 was the most ductile of the three compacted materials. Relative to other excipients, the values for these materials were fairly low, indicating greater ductility. Ductility is a desirable trait that promotes bonding and strength in tablets. 

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