Sodium carboxymethylcellulose, excipient

Spherical pellets containing 5% triamcinolone acet-onide were prepared by Villar-Lopez and coworkers byextrusion/spheronization after formulation with microcrystalline cellulose and/or a hydrophilic excipient such as lactose, sodium carboxymethylcellulose, or p-cyclodextrin. Their suitability for coating, with a view toward colonic drug delivery, was assessed in terms of their size, sphericity, and dissolution test... 

Similar analyses of moisture uptake data available in the literature for other cellulose and starch derivatives used as pharmaceutical excipients are presented in Table 5. Considering the uncertainties associated with the estimated moisture uptake values from published graphs, the values of are all quite consistent with each other and with a stoichiometry of one water molecule per anhydroglucose unit. It is interesting to note that the two samples derived from cellulose, sodium carboxymethylcellulose and sodium croscar-mellose, did not require any correction for degree of crystallinity to conform to close to a 1 1 stoichiometry. It appears quite likely, therefore, that the change in chemical structure and the processing of these materials essentially eliminates the crystallinity of cellulose. 

Although hypromellose and HPMCAS are the dominant cellulosics utilized in the solubilization of poorly soluble drug compounds, most cellulosics accepted as an excipient for pharmaceutical formulation have been studied. These polymers, shown in Table 27.4, include MC, hypromellose phthalate (HPMC-P), EC, carboxymethyl ethylcellulose, hydroxypropyl cellulose, and sodium carboxymethylcellulose. 

Sodimn carboxymethylcellulose is listed in the current U.S. Pharmacopoeia. Its therapeutic applications include use of sodium carboxymethylcellulose as the primary ingredient in bulk-forming laxatives. Excipient uses include use as a suspension aid, a rheology modifier, and as a tablet binder. 

In this chapter, analysis of the excipient in Nasonex (mometasone naral spray) is used as a typical example to demonstrate how to select a proper analytical method. Nasonex Nasal Spray contains Mometasone Furoate, microcrystalline cellulose, and carboxymethylcellulose sodium NF, citric acid USP, sodium citrate USP, benzalkonium chloride solution NF, glycerin USP, polysorbate 80 NF, phenylethyl alcohol USP, and water USP. 

Excipient Carboxymethylcellulose sodium Manufacturer Buckeye Cellulose Corp. Lot No. 9247 AP Magnification 120 x Voltage lOkV... 

Several coprocessed mixtures of microcrystalline cellulose with other excipients such as carrageenan, carboxymethylcellulose sodium, and guar gum are commercially available see Section 17. 

Calcium phosphate dibasic dihydrate Carboxymethylcellulose sodium Hydrolyzed gelatin Sucrose distearate excipient, capsules Dextrates... 

Figure 4 shows the of lyophilized formulations containing various polymer excipients as a function of relative humidity [26], As relative hymidity increased, for each formulation decreased. Formulations containing a, S-poly (vV-hydroxyethyl)-L-aspartamide (PHEA), methylcellu-lose (MC), and hydroxypropylmethylcellulose (HPMC) exhibited comparable r io values at lower humidities than formulations with dextran and carboxymethylcellulose sodium salt (CMC-Na). This indieates that the formulations containing PHEA, MC, and HPMC contain highly mobile protons at a lower temperature than the formulations containing dextran and CMC-Na at the same humidity. 

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