Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Excipient compatibility analysis using isothermal calorimetry

2 Excipient compatibility analysis using isothermal calorimetry [Pg.321]

Isothermal microcalorimetry offers ultimate instrument sensitivity in the nanowatt region, which is 1000-fold greater than traditional DSC. This allows for the detection of reactions at lower, more relevant temperatures, thereby improving the likelihood of valid extrapolations. See Section 8.9.2 for more details of isothermal microcalorimetry. [Pg.321]

When using calorimetry for compatibility testing, it is imperative to realise the nonspecific nature of the technique. Several physicochemical processes can give rise to a calorimetric response, including wetting, evaporation, dissolution, crystallisation and chemical reaction. Isothermal microcalorimery has been previously employed to study the degradation kinetics of drugs in solution [49] and in the solid state [50]. Recently [51], isothermal [Pg.321]

The excipients are grouped according to functionai ciass for comparison reasons [51 ]. [Pg.322]


Excipient compatibility analysis using isothermal calorimetry Microca lo rimetry... [Pg.286]


See other pages where Excipient compatibility analysis using isothermal calorimetry is mentioned: [Pg.156]   


SEARCH



Excipient

Excipient compatibility

Excipients

Isotherm analysis

Isothermal analysis

Isothermal calorimetry (excipient

© 2024 chempedia.info