Excipient compatibility analysis using isothermal calorimetry

2 Excipient compatibility analysis using isothermal calorimetry 

Isothermal microcalorimetry offers ultimate instrument sensitivity in the nanowatt region, which is 1000-fold greater than traditional DSC. This allows for the detection of reactions at lower, more relevant temperatures, thereby improving the likelihood of valid extrapolations. See Section 8.9.2 for more details of isothermal microcalorimetry. 

When using calorimetry for compatibility testing, it is imperative to realise the nonspecific nature of the technique. Several physicochemical processes can give rise to a calorimetric response, including wetting, evaporation, dissolution, crystallisation and chemical reaction. Isothermal microcalorimery has been previously employed to study the degradation kinetics of drugs in solution [49] and in the solid state [50]. Recently [51], isothermal 

The excipients are grouped according to functionai ciass for comparison reasons [51 ]. 

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Excipient compatibility analysis using isothermal calorimetry Microca lo rimetry... 

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