Myocardial imaging agent

Technetium-99m teboroxime is a myocardial imaging agent and is excreted primarily by the hepatobiliary system. It is rapidly taken up by the myocardium and mosdy washes out within 30 minutes. Imaging protocols are performed immediately after injection. The product is a lyopbili ed mixture of boronic acid, dioxine, and other excipients, and the agent is formed with a beating step. 

Fig. 4. Lipophilic-cationic( +1) myocardial perfusion imaging agents A) 99mTc-tetrofosmin R = -CH2CH,0CH,CH3 B), 9"Tc = sestamibi R=C=NCH,C (OCHJ (CH,), Q 99mTc-furifosmin R = -CH2CH2OCH2CH3...

The search for other myocardial imaging agents goes on, and it remains a challenge for coordination chemists to synthesize new complexes based on the known mechanisms of heart uptake and heart retention. As is obvious from the described compounds, a cationic charge is not a necessity, but the mechanism related to the retention of such compotmds has been the most thoroughly studied and rationalized (Scheme 78). 

Cardiac imaging agent for detection of myocardial necrosis Mammalian cells... 

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