Physicochemical Attributes of Pharmaceutical Excipients

For a very long time, scientists generally underestimated the importance of excipients in pharmaceutical dosage forms. Excipients were cheap ingredients viewed solely as inert supports for medicaments. Today, with modern pharmaceutical excipients on the shelf, development of various novel drug delivery systems, and production with high-speed tablet/capsule machines, excipients are rather more than the sugar in the pill.9,10 

However, for low-dose chug products, impurities from excipients can be more problematic for causing chemical stability issues with a drug product. Several commonly used excipients (including povidone, PEG400, polysorbate 80, and hydroxypropyl 

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