Excipient gelatin capsules

Excipients Gelatin capsules Appearance % broken HPMC capsules Appearance % broken ... 

B Jones. Two-piece gelatin capsules excipients for powder products, European practice. Pharm Tech Eur 7(10) 25-34, 1995. 

Over the years there have been many failures with LNIT, due to the absence of standardization and the presence of local adverse reactions, particularly evident with the use of aqueous extracts. These inconvenients are synthesized in little stability (some molecules adhere to the inside surface of the container), autodigestion (presence of proteolytic enzymes in the extracts), and it is impossible to add propellants that enable their vaporization. It has become possible to overcome these problems after the realization of lyophilized allergenic preparations incorporated into an inert excipient in powder (lactose) and included in a rigid gelatine capsule [10, 26],... 

TABLE 6 Liquid Excipients Compatible with Hard Gelatin Capsules... 

Typical solid lipids used are glycerides and/or fatty acids, and may constitute 30% of the formulation. These are from the same family of lipids found in parenteral nutrition emulsions, such as Intralipid, which have been successfully administered intravenously for several decades. Typical excipients are Dynasan 112, composed of short chain fatty acids, Compritol, lecithin, used as an emulsifier, and surfactants such as polysorbate 80, polaxamer 188, PVP, bile salts such as sodium glycocholate, and Span 85. Water can be replaced with oils or PEG 600 to yield dispersions which can be filled into soft gelatin capsules. 

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