Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Drug profiles

The rate and duration of steroid release is affected by (1) polymer composition, (2) drug/polymer ratio (3) microsphere size distribution, and (4) microsphere quality (75). The ratio of glycolide to lactide in the copolymer has been found to be more dominant than the polymer molecular weight in the design of controlled release formulations. Microspheres of smaller size provide in vivo drug profiles of higher levels and shorter durations because of greater surface area. [Pg.17]

The attraction of lipophilicity in medicinal chemistry is mainly due to Corwin Hansch s work and thus it is traditionally related to pharmacodynamic processes. However, following the evolution of the drug discovery process, lipophilicity is today one of the most relevant properties also in absorption, distribuhon, metabolism, excretion and toxicity (ADMET) prediction, and thus in drug profiling (details are given in Chapter 2). [Pg.325]

Chandra, P., and Wright, G. J. Tilorone Hydrochloride. The Drug Profile. 72, 125-148 (1977). Chapuisat, X., and Jean, Y. Theoretical Chemical Dynamics A Tool in Organic Chemistry. 68,... [Pg.164]

Figure 2.6 Compound target activity distribution ( promiscuity ) for 1388 drugs profiled in BioPrint assay panel (with 50% inhibition at 10pM taken as active), shown as a histogram. The number of active compounds is shown along the y-axis and the number of targets along the x-axis (adapted from ref. [6]). Figure 2.6 Compound target activity distribution ( promiscuity ) for 1388 drugs profiled in BioPrint assay panel (with 50% inhibition at 10pM taken as active), shown as a histogram. The number of active compounds is shown along the y-axis and the number of targets along the x-axis (adapted from ref. [6]).
Part 2 Strategic and Technical Aspects of Drug Profiling. 116... [Pg.103]

This part of the chapter will focus on both strategic and technical aspects of drug profiling. We will review the criteria to be taken into consideration for the selection of assays to include in a profile and discuss the new trends in profiling. [Pg.117]

MCQs, contrary to what some students fear, are not meant to be tricky. Do not try to read between the lines but do read the statements very carefully. Many mistakes happen because the directions are not carefully followed. This kind of exercise is part of the test itself, as in pharmacy practice, mistakes are often made because a prescription or the patient s drug profile have not been properly read. [Pg.455]

Models are also useful m strategic project planning to compare the costs and benefits of competing therapies, such as the current standard therapy for schizophrenia and a theoretical drug profile of an antipsychotic designed to improve the therapeutic effect for schizophrenia patients. The costs and benefits can be compared to determine the optimal profile (one that would produce the best possible results) as well as the minimal profile (the properties that a compound must demonstrate to show a clinically meaningful improvement ova the standard therapy). [Pg.315]

For those drugs that are administered as the racemate, each enantiomer needs lo be monitored separately yet simultaneously, since metabolism, excretion or clearance may be radically different for the two enantiomers. Further complicating drug profiles for chiral drugs is that often the pharmacody namics and pharmacokinetics of the racemic drug is not just the sum of Ihe profiles of the individual enantiomers. [Pg.359]


See other pages where Drug profiles is mentioned: [Pg.268]    [Pg.182]    [Pg.25]    [Pg.26]    [Pg.28]    [Pg.30]    [Pg.32]    [Pg.34]    [Pg.36]    [Pg.38]    [Pg.40]    [Pg.42]    [Pg.44]    [Pg.46]    [Pg.48]    [Pg.50]    [Pg.52]    [Pg.442]    [Pg.500]    [Pg.776]    [Pg.94]    [Pg.396]    [Pg.23]    [Pg.238]    [Pg.106]    [Pg.115]    [Pg.117]    [Pg.129]    [Pg.447]    [Pg.176]    [Pg.179]    [Pg.10]    [Pg.111]    [Pg.343]    [Pg.174]    [Pg.128]    [Pg.138]    [Pg.174]   
See also in sourсe #XX -- [ Pg.718 ]




SEARCH



Analytical Profiles of Drug Substances

Drug Targets and Toxicological Profiles by Gene Expression Analysis

Drug metabolism profiling

Drug product dissolution profile

Drug products impurity profile

Drug stability profiles

Drug substances impurity profile

Drug substances purity profiles

Drug substances safety profile

Drug-release profiles

Drugs activity profiles

Drugs drug release profile

Exploratory Profiling of Enzyme Induction on Drug Disposition

Genetic Drug Response Profiles

Humanized mouse models drug profile

Impurity Profiling for Drug Substances and Pharmaceutical Products

In Vitro Profiling Drug Activity, Selectivity and Liability

In vitro drug release profiles

Oral drug profiles

Physicochemical Properties in Drug Profiling

Plasma drug concentration profile

Profiles of Drug Substances, Excipients and Related

Profiles of Drug Substances, Excipients and Related Methodology

Profiling of Drug Absorption, Distribution, Metabolism and Elimination in Man the hADME Study

Profiling the Effect of Food on Drug Bioavailability

Proteomic Profiles to Provide Predictors of Drug-Modulated Targets and Responses

Systemic circulation, drug concentration profiles

Target drug profile

The spatial concentration profile of a drug

Zero-order drug release profiles

© 2024 chempedia.info