Particle Engineering for Developing New Excipients

Flow properties, lubricant sensitivity, aggregation potential, bulk density, compressibility, hygroscopicity 

Particle shape, particle size, particle size distribution, surface area, porosity, surface morphology 

Crystalline (polymorphic / pseudo-polymorphic) amorphous forms 

The spectrum of functionality modification can be substantially enlarged by the coprocessing or particle engineering of two or more existing excipients. Coprocessing involves interaction of two or more excipients at the subparticle level, aimed at 

Particle size Flow ability, content uniformity, compressibility, disintegration, dissolution rate 

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