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Pathway signalling

Wu Y., Tirindelli R, and Ryba N.J. (1996). Evidence for different chemo-sensory transduction pathways signal in olfactory and vomeronasal neurons. Biochem Biophys Res Comm 220, 900-904. [Pg.258]

Lewis TS et al. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Mol Cell 2000 6 1343-1354. [Pg.122]

Deng, C. et al., Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling, Arthritis Rheum., 48, 746, 2003. [Pg.468]

Another way is the intermediate method to bridge the two approaches above. This method determines biologically multiplexed activity profile data. It integrates biological complexity at multiple levels pathways, signal transductions, and environmental factors. [Pg.79]

Phillips AJ, Crowe JD, Ramsdale M, Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans, Proc Natl Acad Sci USA 103 726-731, 2006. [Pg.282]

Fig. 9.12. Overview of the Ras signaling pathway. Signals from at least three major signaling pathways meet at the Ras protein. Activation of the Ras protein may be initiated by receptor tyrosine kinases, by G-protein-coupled receptors and by receptors with associated tyrosine kinases. The nature of the communication between the Ras protein and receptors with associated tyrosine kinase or G-protein-coupled receptors is mostly unknown. From the activated Ras protein, the signal is passed to various effector molecules including members of the MEK kinases, PI3-kinase, pl20 GAP and Ral-GEFs. The best understood is the effector function of Raf kinase, which passes a signal to the transcription level via the MAP kinase pathway. Fig. 9.12. Overview of the Ras signaling pathway. Signals from at least three major signaling pathways meet at the Ras protein. Activation of the Ras protein may be initiated by receptor tyrosine kinases, by G-protein-coupled receptors and by receptors with associated tyrosine kinases. The nature of the communication between the Ras protein and receptors with associated tyrosine kinase or G-protein-coupled receptors is mostly unknown. From the activated Ras protein, the signal is passed to various effector molecules including members of the MEK kinases, PI3-kinase, pl20 GAP and Ral-GEFs. The best understood is the effector function of Raf kinase, which passes a signal to the transcription level via the MAP kinase pathway.
Intracellular signal conduction takes place predominantly by two pathways starting from activated transmembrane receptors. In one pathway, activation of transmem -brane receptors initiates formation of diffusible messenger substances that bind effector proteins and activate these for further signal transduction. In this signaling pathway, signals may be carried as far as the cell nucleus and temporally and spatially variable reactions may be triggered. [Pg.350]

Signaling for apoptosis can be initiated from outside the cell (extrinsic or death receptor pathway) or from inside the cell (intrinsic or mitochondrial pathway) [31, 32]. In both pathways, signaling results in the activation of initiator caspases. Active initiator caspases then sequentially activate downstream effector caspases such as caspase -3, -6, and -7. Once activated, caspases cleave a variety of intracellular polypeptides, including major structural elements of the cytoplasm and nucleus, components of the DNA repair... [Pg.13]

Hoffmann, R., Krallinger, M., Andres, E., Tamames, J., Blaschke, C., Valencia, A. 2005. Text mining for metabolic pathways, signaling cascades, and protein networks. Science STKE. 2005(283) pe21. [Pg.149]

Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, et al. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 2002 3 85-97. [Pg.796]

Bivona TG, Philips MR. Ras pathway signaling on endomem-branes. Curr. Opin. Cell Biol. 2003 15 136-142. [Pg.2092]

C. Chang and J.A. Shockey. 1999. The ethylene-response pathway Signal perception to gene regulation Curr. Opin. Plant Biol. 2 352-358. (PubMed)... [Pg.1028]

MAP kinase pathways signaling pathway utilized by cells to respond to extracellular stimuli. Activation of this pathway regulates varied cellular activities including gene expression, mitosis, differentiation, and cell survival/apoptosis. [Pg.781]

DeVIVO M, Iyengar R. G protein pathways signal processing by effectors. Mol Cell Endocrinol 100 65-70, 1994. [Pg.221]

Possible future pharmacological treatments could be based on the inhibition of proinflammatory mediators, prevention of adhesion between the leukocytes and endothelial cells, controlling the specific transduction pathway signals following cytokine production and promoting neovascularization. Strategies that block the activity of inflammation-induced enzymes, such as iNOS and COX-2 should also be investigated. [Pg.195]

Protein kinases are central to many signal-transduction pathways. Protein kinases are central to all three signal-transduction pathways described in this chapter. In the epinephrine-initiated pathway, cAMP-dependent protein kinase (PKA) lies at the end of the pathway, transducing information represented by an increase in cAMP concentration into covalent modifications that alter the activity of key metabolic enzymes. In the insulin- and EGF-initiated pathways, the receptors themselves are protein kinases and several additional protein kinases participate downstream in the pathways. Signal amplification due to protein kinase cascades are common features of each of these pathways and many others. Furthermore, protein kinases often phosphorylate multiple substrates, including many not considered herein, and by this means are able to generate a diversity of responses. [Pg.399]


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See also in sourсe #XX -- [ Pg.138 , Pg.150 , Pg.202 ]




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Accelerated Fe-S switch by a signaling pathway

Analog-specific Kinases kinase-signaling pathways

Apoptosis and Cellular Signaling Pathways

Apoptotic signal transduction pathways

Apoptotic signaling pathways

Apoptotic signaling pathways calcium

Apoptotic signaling pathways ceramides

Aryl hydrocarbon receptor signaling pathway

Biosynthesis signal transduction pathway

Biotin signalling pathways

CAMP signaling pathway

CAMP/PKA signaling pathway

CD95 signaling pathways

Calcium signaling pathways

Calmodulin signaling pathways

Cell signaling pathways

Cell signaling pathways isoflavone activation

Cells signalling pathways

Cellular signaling pathway

Coupled signaling pathways

Cytokines signaling pathways

Developmental signaling pathways

Domain families GTPase-mediated signaling pathways

Domain families signaling pathways

ERK signaling pathway

Embryo signaling pathways

Epidermal growth factor receptor signaling pathway

Estrogen receptor transduction signal pathway

Estrogen receptor-mediated signaling pathway

Estrogen signalling pathway

Eukaryotic Stress Response Signaling Pathways as Mechanistic Targets for Functional Foods

Evolution signal transduction pathways

Extracellular signal-regulated kinase pathway

Extracellular signal-regulated kinase signaling pathway

Extracellular signal-regulated protein kinase pathway)

Fas signaling pathway

Fatty acid desaturation signalling pathways controlling

Function and Structure of Signaling Pathways

G-protein Coupled Signal Transmission Pathways

G-protein-coupled receptor signaling pathway

G-proteins signaling pathway

GH Signaling Pathways Involving STAT Transcription Factors

GTPase, signaling pathway mediation

GTPases signalling pathways

General Function of Signal Pathways

Hedgehog signaling pathway

Hedgehog signalling pathway

Histamine signaling pathways

Hypoxia-regulated signal transduction pathways

Inflammation lipid signaling pathways

Inflammatory signaling pathways

Inhibitors of NFkB and Other Intracellular Signalling Pathways

Insulin signaling pathway

Insulin signalling pathways

Insulin/IGF signaling pathways

Intracellular signal transduction pathway

Intracellular signaling pathways

Intracellular signaling pathways, activation

JAK-STAT signaling pathway

JAK/STAT signalling pathway

Lymphocyte signal transduction pathways

MAP kinase signal transduction pathway

MAP kinase signaling pathway

Mechanotransduction signalling pathways

Mediated intracellular signaling MAPK pathway

Mediated intracellular signaling pathways

Mitogen-activated protein kinase signaling pathway

Modulation of redox signaling pathways

Mood disorders intracellular signalling pathways

NF-kB signalling pathway

NO-cGMP signaling pathway

Neuron signaling pathways

Neurotrophin receptors, signaling pathways

Neurotrophins signaling pathway

Nitric oxide signaling pathways

Nitric-oxide synthases signal transduction pathways

Notch signaling pathway

Novel signalling pathways

ORF74 Constitutively Activates Multiple Signaling Pathways in Different Cell Types

Optical Analysis of the Oxygen-Sensing Signal Pathway

Oxidative stress signaling pathway promoting

P-adrenergic signal transduction pathway

P38 MAPK signaling pathway

PI 3-kinase signaling pathway

Participation of the Transcriptional Co-Activator CBP in Several Signaling Pathways

Phosphatidylinositol signaling pathways

Phosphatidylinositol-3-kinases signaling pathways

Phosphoinositide 3-kinase signaling pathways

Phosphorylation signalling pathways

Plasma membrane-associated signaling pathways

Platelets signaling pathways

Pro-inflammatory signaling pathways

Protein kinases signal transduction pathways, study

RAS and the MAP Kinase Signaling Pathway

Ras signaling pathway

Reaction Signalling pathway

Receptor mediated signaling pathways

Receptor protein tyrosine kinases, signal pathways

Receptor tyrosine kinases signaling pathways

Redox signaling pathway

Redox signaling pathways, modulation

Regulation of signaling pathways

Retinoic acid signaling pathways

Signal Pathways Operated by Receptor Protein Tyrosine Kinase

Signal Transduction via the Two-component Pathway

Signal pathway-associated proteins

Signal pathway-associated proteins calmodulin

Signal pathways

Signal pathways

Signal transduction inflammation pathways

Signal transduction pathway zoospore

Signal transduction pathways

Signal transduction pathways chemical inhibition

Signal transduction pathways controlling morphogenesis and haematopoiesis

Signal transduction pathways mathematical modeling

Signal transduction pathways model

Signal transduction pathways organization

Signal transduction pathways shear stress

Signal transduction pathways through heterotrimeric G proteins transmission of hormonal and sensory signals

Signal transduction pathways through small monomeric G proteins

Signal transduction pathways---kinase inhibition

Signaling Pathways for Regulating Adipocyte Formation

Signaling pathway

Signaling pathway

Signaling pathway General functions

Signaling pathway General structure

Signaling pathway complications

Signaling pathway convergent

Signaling pathway crosstalk

Signaling pathway divergent

Signaling pathways binding, cell surface receptors

Signaling pathways protein kinase family

Signaling pathways protein tyrosine kinases

Signaling pathways tyrosine kinases

Signaling pathways within platelet

Signaling pathways, Effects

Signaling pathways, influence

Signaling pathways, modulation

Signaling stress pathways

Signaling transduction pathways

Signalling pathway regulation

Signals transduction pathways and

Smad signaling pathway

Sonic hedgehog signaling pathway

Sphingomyelin signalling pathway

Stem Cell Signaling Pathways for Migration, Proliferation, and Differentiation

Steroid hormone receptor Signaling pathway

Stress kinases signal transduction pathways

Structure of Signaling Pathways

Systems biology signal pathways

T cells signalling pathways

TGF-P Signaling Pathway

The Janus Family Tyrosine Kinases-Signal Transducers and Activators of Transcription Signaling Pathway

The role of signaling pathways

Wnt signaling pathway

Wnt signalling pathway

Wnt signalling pathway, and

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