Stress kinases signal transduction pathways

Kyriakis JM, Avruch J. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81 807-869. 

Phosphorylation of H3 is not limited to mitosis and also occurs in G1 phase of the cell cycle. Activation of the Ras-Raf-MEK-ERK signal transduction pathway and/or of the p38 stress kinase pathway when cells are treated with epidermal growth factor (EGF), 12-G-tetradecanoylphorbol-13-acetate (TPA), anesomycin, okadiac acid, and stresses such as UV irradiation induces the rapid phosphorylation of H3 at Ser-10 and/or Ser-28 [68-72] (Figs. 5 and 6). Inhibition of the MEK1,2 activity with PD98059 prevents the activation of ERK and TPA-induced H3... 

Fig. 2 Outline of signal transduction pathways for stress kinases, JNKs, and for Map kinases, p38 and ERKl/2. Shown is the cross-talk between the various pathways. Map kinases MEKKl/2/3 activate the MAP kinases MKK4 (JNKKl) and MKK7 (JNKK2). MKK4/7 can also be activated by the Map kinases TAKl and Askl, which can also activate MKK3/6 of the p38 s pathway. Activation of Rap-GTP is capable of activating the p38 and ERKl/2 pathways. As indicated, ceramide can activate the p38 pathway, and, also, has been suggested to play a role in activation of the ERKl/2 pathway...

Kuroki, D.W., et al.. Regulation of a c-Jun amino-terminal kinase/stress-activated protein kinase cascade by a sodium-dependent signal transduction pathway, J. Biol. Chem., 272, 23905, 1997. 

Signal transduction (control of cellular stress responses and MAP-kinase pathways)... 

Wang, W., et al.. Activation of the hematopoietic progenitor kinase-1 (HPKl)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAKl), a kinase mediator of TGF beta signal transduction. J Biol Chem, 1997,... 

Stimulation of ovarian granulosa cells with follicle-stimulating hormone results in the phosphorylation of H3 at Ser-10 [74]. However, neither the Ras-Raf-MEK-ERK signal transduction nor the p38 stress kinase pathways are involved in this response. 

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