Hedgehog signaling pathway

Maniatis, T., a ubiquitin ligase complex essential for the NF-B, Wnt/ Wingless, and Hedgehog signaling pathways. Genes Dev, 1999, 13, 505— 510. 

Basal cell carcinoma Mutation PTCH, SMO SMO (hedgehog signaling pathway) Vismodegib... 

Wu X, et al. Purmorphamine induces osteogenesis by activation of 54. the hedgehog signaling pathway. Chem. Biol. 2004 1 1229-1238. 

Buttner A, Seifert K, Cottin T, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 17(14) 4943-4954. 

Katoh, Y., and Katoh, M. (2005). Hedgehog signaling pathway and gastric cancer. Cancer Biol Ther 4(10), 1050-1054. 

Finally, recent research has indicated that other human diseases, such as the commonest form of skin cancer, basal cell carcinoma, are caused by mutations in genes involved in the Sonic hedgehog signalling pathway. The Patched (Ptc) gene encodes a Sonic hedgehog receptor [92,93] and a tumor suppressor protein that is defective in basal cell nevus syndrome [94]. 

Activated hedgehog signaling pathway SMO inhibitor cyclopamine... 

Katoh M. Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis. Stem Cell Rev 2007 3 30-38. 

Slusarz A, Shenouda NS, Sakla MS, Drenkhahn SK, Narula AS, MacDonald RS, Besch-Williford CL, Lubahn DB (2010) Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer. Cancer Res 70 3382-3390... 

Wang LC et al (2000) Regular articles conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration. J Invest Dermatol 114(5) 901-908... 

Later on, Waldmann s group described a novel highly enantioselective method for the synthesis of an iridoid-inspired compound collection by the kinetic resolution of racemic 2//-pyran-3(6//)-one derivatives by means of an asymmetric [3+2] cycloaddition with azomethine ylides using this catalytic system (Scheme 15) [27]. The desired products were formed efficiently with high stereoselectivity and led to the discovery of a new class of inhibitors of the Wnt and hedgehog signaling pathways. 

Heretsch P, Tzagkaroulaki L, Giannis A (2010) Modulators of the hedgehog signaling pathway. BioorgMed Chem 18 6613-6624... 

---