CAMP signaling pathway

Abnormalities in G protein subunits/cAMP signaling pathway have been observed in bipolar disorder 897... 

The calcium-phosphoinositide and cAMP signaling pathways oppose one another in some cells and are complementary in others. For example, vasopressor agents that contract smooth muscle act by IP3-mediated mobilization of Ca2+, whereas agents that relax smooth muscle often act by elevation of cAMP. In contrast, cAMP and phosphoinositide second messengers act together to stimulate glucose release from the liver. 

Berg ]P and Hang E (1999) Vitamin D a hormonal regulator of the cAMP signalling pathway. Critical Reviews in Biochemistry and Molecular Biology 34,315-23. 

Figure 8 Simplified diagram of a signaling cascade that involves NE, BDNF, and CREB after NE acts on the postsynaptic fi-noradrenergic receptor. NE couples to a G protein (Gas), which stimulates the production of cAMP from adenosine triphosphate (ATP). This reaction is catalyzed by adenylate cyclase (AC). cAMP activates protein kinase A (PKA). Inside the cell, PKA phosphorylates (P) the CREB protein, which binds upstream from specific regions of genes and regulates their expression. BDNF is one target of cAMP signaling pathways in the brain. CRE, cyclic AMP regulatory element ER, endoplasmic reticulum, [reprinted from Reference 76 with permission of the author and the publisher, Canadian Medical Association].

Rybin VO, Xu XH, Lisanti MP, Steinberg SF. Differential targeting of P-adren-ergic receptor subtypes and adenyly 1 cyclase to cardiomyocyte caveolae a mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem 2000 275 ... 

Atkins CM, OUva AA Jr, Alonso OF, Pearse DD, Bramlett HM, Dietrich WD (2007a) Modulation of the cAMP signaling pathway after traumatic brain injury. Exp Neurol 208 145-158... 

Daoust, J., Fontana, A., Merchant, C.E., de Voogd, N.J., Patrick, B.O., KiefFer, T.J., and Andersen, R.J. (2010) Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteomarginata and the sponge Phorbas sp., activates the cAMP signaling pathway. Org. Lett., 12, 3208-3211. 

Ansellone A is a new sesterterpene isolated from the couple Cadlina luteomarginata/Phorhas sp., collected near Ansell Point, British Columbia. This compound displays the new carbon skeleton of ansellane that formally associates a drimane and a menthane skeleton. Anselone A activates the cAMP signaling pathway (Daoust et al, 2010). 

The cAMP signaling pathway is a G-protein-coupled receptor (GPCR) which intervenes in cell communication. 

Hoffinan CS, Winston F (1991) Glucose repression of ttanscription of the Schizomccharomycespombe fbpl gene occurs by a cAMP signaling pathway. Genes Dev 5 561-571... 

Moore MS et al (1998) Ethanol intoxication in Drosophila genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93 997-1007... 

---