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Neuron signaling pathways

Spencer JPE. 2007. The interactions of flavonoids within neuronal signalling pathways. Genes Nutr 2 257-273. [Pg.48]

Grb-2 facilitates the transduction of an extracellular stimulus to an intracellular signaling pathway, (b) The adaptor protein PSD-95 associates through one of its three PDZ domains with the N-methyl-D-aspartic acid (NMDA) receptor. Another PDZ domain associates with a PDZ domain from neuronal nitric oxide synthase (nNOS). Through its interaction with PSD-95, nNOS is localized to the NMDA receptor. Stimulation by glutamate induces an influx of calcium, which activates nNOS, resulting in the production of nitric oxide. [Pg.16]

Many environmental toxins interact with specific cellular receptors, including enzymes, ion channels and ion pumps, and thus provide natural tools for the study of cellular signalling pathways. Palytoxin, a compound isolated from the coelen-terate of genus Palythoa, is one such useful and intriguing compound. The structure of palytoxin was first determined in 1981 independently by Hirata (7) and Moore (2). As one of the most potent marine toxins known, palytoxin has been studied in a variety of systems ranging from erythrocytes to neurons. As a tumor promoter of the non 12-O-tetradecanoylphorbol-13-acetate (TPA) type, palytoxin can also be studied in the context of a growth control system. [Pg.204]

Lieberam I, Agalliu D, Nagasawa T, Eiicson J, Jessell TM (2005) A Cxcll2-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron 47 667-679... [Pg.216]

The Effect of CXCR4-Mediated Signaling Pathway on Neuronal Activity and Neurotransmitter Release... [Pg.273]

Number of papers to date have shown that the CXCR4 receptors expressed in both neuronal and glial cells are functional and coupled to multiple intracellular pathways (Lazarini et al. 2003). The CXCR4 through pertussis toxin (PTX)- sensitive G proteins is coupled to at least two distinct signaling pathways (1) the first pathway, involving the activation of phosphatidylinositol- 3 (PI-3) kinase and extracellular signal... [Pg.273]

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See also in sourсe #XX -- [ Pg.1775 ]



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Neuronal signalling

Neurons signals

Pathway signalling

Signal pathways

Signaling pathway

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