Epidermal growth factor receptor signaling pathway

Sah JF, Balasubramanian S, Eckert RL and Rorke EA. 2004. Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases. J Biol Chem 279(13)42755-12762. 

Tanaka-Kagawa, T. et al., Arsenite and arsenate activate extracellular signal-regulated kinases 1/2 by an epidermal growth factor receptor-mediated pathway in normal human keratinocytes, Br. J. Dermatol., 149, 1116, 2003. 

Oda K, Matsuoka Y, Eunahashi A, Kitano H. A comprehensive pathway map of epidermal growth factor receptor signaling. Mol. Syst. Biol. 2005 1 1-17. 

Filardo EJ (2002) Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30 a novel signaling pathway with potential significance for breast cancer. J Steroid Biochem Mol Biol 80 231... 

Deoxycholic acid has also been demonstrated to activate other pivotal oncogenic pathways in CRC cells in vitro including p-catenin/T-cell factor-mediated transcription, extra-cellular signal-regulated kinase activation downstream of the epidermal growth factor receptor and Jun-N-terminal kinase... 

Further examples of substrates of protein kinase C are the epidermal growth factor receptor (see Chapter 8), a Na7H exchanger protein, and Raf kinase (Chapter 9). Activation of protein kinase C may, as the examples show, act on other central signal transduction pathways of the cell it may have a regulating activity on transcription processes and it is involved in the regulation of transport processes. Many substrates of protein kinase C are membrane proteins and it is evident that membrane association of protein kinase C is of great importance for the phosphorylation of these proteins. 

Inhibition of Epidermal Growth Factor Receptor (EGFR)-Mediated Pathways 175 Inhibition of Insulin-like Growth Factor (IGF)-I Mediated Signal Transduction Pathway 175... 

The importance of STAT proteins as signal transducers and transcriptional regulators became clear when it was found that the epidermal growth-factor receptor also stimulates tyrosine kinases, which in turn, phosphorylate STATl-a and another family member, STAT3. Since STAT proteins function as phosphorylation-dependent multisubunit transcription factors, the signaling pathways can be cell-type specific, depending on which Jak kinases are expressed and on the relative abundance of various STAT family members. 

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