T cells signalling pathways

Mandel S, Weinreb O, Amit T, Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (—)-epigallocatechin-3-gallate, implications for neurodegenerative diseases, JNeurochem 88 1555—1569, 2004. 

Structurally diverse compounds like the undecapeptide cyclosporin A and the complex polyketide FK506 bind similar biological target molecules, the immuno-philins, and interfere with identical T cell signaling pathways. 

In experimental models, the immunosuppressant cyclosporine A blocks T-cell signalling pathways by inhibiting the phosphatase calcineurin and may induce autoimmunity by impairing central tolerance... 

Activation of T cell signaling pathways Increase in the expression of LFA-1 and cytokines... 

Bacon KB, Premack BA, Gardner P, SchaU TJ. Activation of dual T cell signaling pathways by the chemokine RANTES. Science 1995 269 1727-1730. 

Juncadella IJ, Garg R, Ananthanarayanan SK et al. T-cell signaling pathways inhibited by the tick saliva immunosuppressor, salplS. FEMS Immunol Med Microbiol 2007 49(3) 433-438. 

Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM. 1999. N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J Biol Chem 274(44) 31740-31749. 

Corasaniti, M. T., Maiuolo, J., Maida, S., Fratto, V., Navarra, M., Russo, R., Amantea, D., Morrone, L. A., and Bagetta, G. (2007). Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in vitro. Br. J. Pharmacol. 151,518-529. 

Sachs K, Gifford D, Jaakkola T, Sorger P, Lauffenburger DA. Bayesian network approach to cell signaling pathway modeling. 

A very simple version of the cell-signaling pathway involving RAS and MAP kinase is shown in Figure 11,10, Step 1 depicts a hormone (in the bloodstream) binding to its receptor in the plasma membrane Step 2 shows RAS, in the cytoplasm, binding to the inside of the plasma membrane, and the consequent activation of RAS. Step 3 shows the phosphorylation of JTJN, and the production of an active transcription factor (JUN-phosphate). JUN-phosphate, in turn, binds to the jUN response element on t>NA and provokes the activation of a nearby gene. 

Wiseman, S., Mulder, T., and Rietveld, A. 2001. Tea flavonoids Bioavailability in vivo and effects on cell signaling pathways in vitro. Antiox. Redox Signal 3 1009-21. 

Hancock, J.T., R. Desikan, and S.J. Neill Role of reactive oxygen species in cell signaling pathways Biochem. Soc. Transactions 29 (2001) 345-350. 

Mandel SA, Amit T, Kalfon L, Reznichenko L, Weinreb O, Youdim MB (2008) Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols special reference to epigallocatechin gallate (EGCG). J Alzheimer s Dis 15(2) 211-222... 

Forestieri, R., Merchant, C.E., de Voogd, N.J., Matainaho, T., Kieffer, T. J., and Andersen, R.J. (2009) Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway. Org. Lett, 11, 5166-5169. 

---