Embryo signaling pathways

Goutte, C., Tsunozaki, M., Hale, V. A. and Priess, J. R. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl Acad. Sci. USA 99 775-779, 2002. 

Morisato, D., Anderson, K.V. Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Annu Rev Genet 1995, 29 371-399. 

Early life stages of zebrafish have also been proposed as models to study the immune response. The innate immune response or components of the underpinning signaling pathways are already established in zebrafish embryos, and proinflammatory responses provoked by pathogens have been observed.90-93 However, immune modulation by drugs has yet not been addressed in fish embryos. 

Alcohol toxicity has not been the primary focus of investigations using zebrafish. Instead, zebrafish have been treated with very high doses of alcohol in order to perturb a particular developmental and/or signaling pathway of interest. Exposure of zebrafish embryos to alcohol causes cyclopia, craniofacial abnormalities, and alters gene expression in the ventral aspects of the fore- and mid-brain . Alcohol exposure of zebrafish embryos also induces stress proteins , developmental... 

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