Inflammation lipid signaling pathways

Kinases, also referred to as phosphotransferases, are key modulators of a variety of cellular and biochemical pathways and are known to phosphorylate a host of substrates including lipids, proteins, nucleotides, aminoacids and carbohydrates, thereby facilitating intracellular signaling. From a traditional standpoint, the inhibition of dysregulated kinases has received considerable focus in drug discovery to treat a number of diseases such as inflammation, cancer and diabetes. 

Initially, the resolution of acute inflammation was thought to be a passive process, that eventually takes place without the active involvement of particular pathways or mediators. Recent investigations, however, revealed that resolution is an active process mediated by certain molecular mediators that activate pro-resolving biochemical pathways and cellular signaling. Notably, several lipid mediators derived from ARA, EPA, and DHA were shown to play major roles in promoting resolution [1-4]. 

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