Estrogen receptor-mediated signaling pathway

Min, G., Kim, H., Bae, Y., Petz, L., and Kemper, J. K. (2002) Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching pi 60 coactivators.. /. Biol. Chem. Ill, 34626-34633. 

S. Kato, Estrogen receptor-mediated cross-talk with growth factor signaling pathways, Breast Cancer 2001, 8, 3-9. 

A further mode of action of endocrine disrupters that has been reported is an ER-independent anti-estrogenity mediated by AhR ligands such as TCDD and/or PAHs. This indicates substantial cross-talk between signalling pathways of different nuclear receptors (Zacharewski et al., 1991). Table 3.4.4 reports mode of action of the main ER sensitive environmental contaminants. 

The mechanism of repulsion or negative chemotaxis in zoospores is not yet kiK)wn, but in bacteria Ix activities are mediated by the modification of common receptor and signal transduction pathways (29). Notably, while several isoflavones with structural similarity to daidzein functioned as chemoattractants for Ph, sojacy many related flavonoids had repellent activities (i9). The importance of flavonoids in the case of Ph. sojae, and estrogenic substances in the case of A. cochlioides, in deterring infection of nonhost plants, certainly warrants additional investigation. 

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