Novel signalling pathways

Maffucci T, Cooke FT, Foster FM, Traer CJ, Fry MJ, Falasca M. Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. J Cell Biol 2005 169(5) 789-799. 

Filardo EJ (2002) Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30 a novel signaling pathway with potential significance for breast cancer. J Steroid Biochem Mol Biol 80 231... 

Skov S, Rieneck K, Bovin LE, Skak K, Toim-a S, Michelsen BK, Odum N (2003) Histone deacetylase inhibitors a new class of iimnimosuppressors targeting a novel signal pathway essential for CD154 expression. Blood 101 1430-1438... 

Lenglet S, Louiset E, Delarue C, Vaudry H, Contesse V. Involvement of T-type calcium channels in the mechanism of action of 5-HT in rat glomerulosa cells a novel signaling pathway for the 5-HT7 receptor. Endocr Res 2002 28 651-655. 

Senogles SE (2000) The D2s dopamine receptor stimulates phospholipase D activity a novel signaling pathway for dopamine. Mol Pharmacol 55 455-462. 

In this review, we consider the regulation of cellular localization and trafficking of the family of ARs. Because cellular trafficking appears to be inexorably linked to the activation of novel signaling pathways and the formation of signaling packages within the cell, we also include a discussion of these processes. 

Despite the described progress in many fields of nuclear receptor research which has also resulted in the determination of novel signalling pathways, for a... 

Components of the JAK-STAT signaling pathway represent novel targets for pharmacological interventions [4]. Recently, a specific and orally active JAK3 antagonist was identified from screening of a chemical library for inhibitors of in vitro JAK3 kinase activity. The most effective compound, CP-690,550, was shown... 

Luu HH, Zhang R, Haydon RC et al (2004) Wnt/p-catenin signaling pathway as novel cancer drug targets. Cun-Cancer Drug Targets 4(8) 653-671... 

Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, et al. An orphan nnclear receptor activated by pregnanes defines a novel steroid signalling pathway. Cell 1998 92 73-82. 

Marchese AM et al. Discovery of three novel orphan G-protein-coupled receptors. Genomics 1999 56 12-21. Bertilsson G et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 1998 95 12208-12213. 

Liu R, Li Z, Bai S, et al. Mechanism of cancer cell adaptation to metabolic stress proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway. Mol. Cell. Proteomics 2009 8 70-85. 

McDonnell DP (2003) Mining the complexities of the estrogen signalling pathways for novel therapeutics. Endocrinology 144 4237-4240... 

Kliewer, S.A., Lehmann, J.M., Milburn, M.V. and Willson, T.M. (1999) The PPARs and PXRs nuclear xenobiotic receptors that define novel hormone signaling pathways. Recent Progress in Hormone Research, 54, 345-367. 

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