Platelets signaling pathways

Xu Y. and Tao Y. X. (2004). Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. NeuroReport 15 263-266. 

Agonist stimulation of platelet receptors induces various internal signaling pathways transduced from the membrane into the cytoplasm, which result in platelet receptors GPIIb/llla activation. 

Many platelet agonists, such as ADF) TXA2, epinephrine, serotonin, and thrombin, interact with specific transmembrane receptors that are coupled to G-proteins, initiating several signaling pathways that lead to PLC activation ending in platelets shape change and granule secretion (Fig. 4). 

Coffey MJ, Jarvis GE, GibbinsJM, etal. Platelet 12-lipoxygenase activation via glycoprotein VI. Involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis. Circ Res 2004 94 1598-1605. 

Nick, J. A., Avdi, N. J., Young, S. K., Knall, G., Gerwins, P., Johnson, G. L., and Worthen, G. S. (1997). Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J. Clin. Invest. 99, 975-986. 

A. Pandey, A. V. Podtelejnikov, B. Blagoev, X. R. Bustelo, M. Mann, and H. F. Lodish, Analysis of receptor signaling pathways by mass spectrometry Identification of Vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors, Proc. Natl. Acad. Sci. USA 97 (2000), 179-184. 

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