Notch signaling pathway

Goutte, C., Tsunozaki, M., Hale, V. A. and Priess, J. R. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl Acad. Sci. USA 99 775-779, 2002. 

The Notch signaling pathway is thus a further example of signal conduction in which the signal is directed by the shortest pathway from the cell membrane into the nucleus. 

Tonon G, Modi S, Wu L, et al. t(ll 19)(q21 pl3) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts Notch signaling pathway. Nature Genet. 2003 33 208-213. 

The Conserved Notch Signaling Pathway Mediates Lateral Inhibition... 

Chen IS, Pedro MS, Zeller RW. miR-124 function during Ciona intestinalis neuronal development includes extensive interaction with the Notch signaling pathway. Development 2011 138 49343-4953. 

The Notch signaling pathway is also important for determining cell fate in HF development [87]. Notch signaling acts by blocking cell differentiation, which maintains the competence of undifferentiated cells [88, 89] in both the developing tooth and the HF to respond to inductive signals that determine their developmental fate [87, 90]. Based on expression smdies in the HF, Notch may be a competence factor, as its pattern of expression in the HF appears to be restricted to cells that have left the proliferative pool but have yet to terminally differentiate [91, 92]. 

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