Signal transduction pathways shear stress

The intracellular signal transduction pathway that is initiated by increases in shear stress has been reported to involve activation of phospholipase C (Bhagyalakshmi et al., 1992) and a rapid increase in intracellular levels of inositol 1,4,5-trisphosphate (Nollert et al., 1990 Prasad et al.,... 

The involvement of Ca in the signal transduction pathway that translates shear stress into an immediate increase in NOS activity has, for some time, been controversial, and the response to shear stress has often been confused with mechanical perturbation. Recent data obtained using more sophisticated techniques have established that shear stress indeed increases [Ca ]j both in cultured cells and in endothelial cells in situ (Falcone et al.,... 

Kapur, S., D. J. Baylink, and K. H. Lau 2003. Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. Bone 32(3) 241-51. 

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