Healing, wound

In addition, protective and water-insoluble biodegradable films based on gellan have been prepared, characterized and evaluated for their effects on the wound healing process. The prepared films were further crosshnked with l-ethyl-3-(3-dimethylaminopropyl) carbodiimide crosslinker (EDC) to provide a optimum mechanical strength and make 

Hoelgaard (1991) prepared HGH in soft, porous, flexible sheets from hydroxyethyl cellulose and poly(ethylene glycol) 6000 using a lyophilization process. The HGH biological activity as measured by rat tibia test and HGH-receptor assay was reportedly maintained. 

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Human growth hormone, used as a human pharmaceutical, is approved for only one indication in the United States, treatment of growth failure owing to hGH deficiency, a condition known as pituitary dwarfism. However, clinical trials are under way to test its efficacy in Turner s syndrome, bums, wound healing, cachexia, osteoporosis, constitutional growth delay, aging, malnutrition, and obesity. 

Pharmaceutical Applications. Sucrose has a long history in the manufacture of pharmaceuticals. It imparts body to symps and medicinal hquids and masks unpleasant tastes. Sucrose also functions as a diluent to control dmg concentrations in medicines, as an ingredient binder for tablets, and to impart chewiness to the latter. Sustained-release medications and protective tablet glazes are prepared using sucrose (41). Sucrose-based sugar pastes are used to promote wound healing (58). 

In paints, zinc oxide serves as a mildewstat and acid buffer as well as a pigment. The oxide also is a starting material for many zinc chemicals. The oxide supphes zinc in animal feeds and is a fertilizer supplement used in zinc-deficient soils. Its chemical action in cosmetics (qv) and dmgs is varied and complex but, based upon its fungicidal activity, it promotes wound healing. It is also essential in nutrition. Zinc oxide is used to prepare dental cements in combination with eugenol and phosphoric and poly(acrylic acid)s (48) (see Dental materials). 

Insufficient zinc results in slowed growth, delayed wound healing, poor appetite, mental lethargy, and sexual immaturity and it interferes with the immune response. The main function of zinc in metaboHsm is enzymatic and there is evidence of other physiologic roles, eg, in stabilization of membrane stmcture (57). 

Congenital deficiency of Factor Xlll is inherited as an autosomal recessive trait and is frequendy recognized at birth because of delayed persistent hemorrhage from the umbiUcus. In Factor Xlll-deficient people wound healing is defective and wound dehiscence is common. 

A skin wound cleanser is a nonirritating, Hquid preparation (or product to be used with water) that assists in the removal of foreign material from small superficial wounds, does not delay wound healing, and may contain an antimicrobial ingredient. 

Hydroxymethyl-6-methyluracil (1043) was prepared many years ago from 6-methyl-uracil and formaldehyde, or in other ways. Since 1956 it has received much attention in the USSR under the (transliterated) name pentoxyl or pentoxil. It is used in several anaemic and disease conditions. For example, a mixture of folic acid and pentoxyl quickly reduces the anaemia resulting from lead poisoning pentoxyl stimulates the supply of serum protein after massive blood loss it stimulates wound healing it stimulates the immune response in typhus infection and it potentiates the action of sulfonamides in pneumococcus infections (70MI21300). 

Spotnitz, W.D., Falstrom, J.K. and Rodeheaver, G.T., The role of sutures and fibrin sealant in wound healing. In Barbul, A. (Ed.), Surgical Clinics of North America — Wound Healing. W.B. Saunders, London, 1997, pp. 1-19. 

Contact inhibition is observed in the process of wound healing and describes the ability of a tissue to stop cell proliferation again after cellular multiplication has filled up the defect caused by a wound. 

Panthenol is frequently used in ointments and solutions for the treatment of burns, anal fissures, and inflammation of the conjunctiva. The vitamin has to be substituted in patients on total parenteral nutrition and in those who regularly undergo dialysis. Hypervitamin-osis has not been observed for doses up to 5 g/d (22). Furthermore, the administration of pantothenic acid leads to improved surgical wound healing due to its antiinflammatory properties. 

Epidermal Maturation and Wound Healing. All three PPAR isotypes are expressed during epidermal maturation each isotype has a specific pattern of expression in regard to development and the various layers of the epidermis. An important role for PPARS in the development and/or maintenance of normal skin health is indicated by the presence of defective wound healing in the PPARS-null mouse. 

Elson ML (1998) The role of retinoids in wound healing. J Am Acad Dermatol Suppl 39 79-81... 

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