Healing process, wound

Recently, the notion that the chronicity of inflammation may not actually drive the fibrogenic process has been widely appreciated (Tables 1, 2, and 3). Some propose that it is indeed the alteration of the mesenchymal cell phenotypes that disrupts the balance between collagen synthesis and degradation in the wound-healing process, highlighted by clinical evidence that shows unsuccessful treatment of fibrosis with anti-inflammatory or immunosuppressive drugs (18,19). One scenario is that mesenchymal cells (myofibroblasts and fibroblasts) are phenotypically altered and thus do not undergo apoptosis after resolution. 

PDGF plays an important role in the wound healing process. It is released at the site of damage by activated platelets, and acts as a mitogen/chemoattractant for many of the cells responsible for initiation of tissue repair. It thus tends to act primarily in a paracrine manner. It also represents an autocrine/paracrine growth factor for a variety of malignant cells. 

Knowing that nitric oxide and hyaluronic acid both play an important role in the wound healing process, Di Meo et al. chose to combine the properties of both entities and synthesized new NO-donors based on hyaluronic acid derivatives exhibiting a controlled NO-release under physiological conditions (in vitro tests). These derivatives were fully characterized by and 13C NMR spectroscopy and their NO release monitored by means of UV spectrophotometric measurements.47... 

The ability of such factors to promote accelerated cellular growth and division has predictably attracted the attention of the pharmaceutical industry. The clinical potential of a range of such factors, e.g. to accelerate the wound-healing process, is currently being assessed in various clinical trials (Table 7.2). 

Because irradiation interferes with the natural wound-healing process, it is an important prerequisite of successful application of irradiation that mature tubers with fully developed periderm are suitable for radiation processing and tubers must be properly cured from harvesting and handling injuries before irradiation. 

The normal wound healing process is a concerted effort between multiple cell types including leukocytes (monocytes, macrophages, platelets, granulocytes, and... 

Vaxman F, Olender S, Lambert A, Nisand G, Aprahamian M, Bruch JF, Didier E, Volkmar P, and Grenier JF (1995) Effect ofpantothenic acid and ascorbic acid supplementation on human skin wound healing process. A douhle-hlind, prospective and randomized trial. European Surgery Research 27, 158-66. 

Active wound dressings, which not only control the environmental conditions during the healing process but actively take part in the wound healing process. 

Heidemann D. Wundheiliungsstorungen nach Chlorhexidin-Anwedung ein Fallbericht. [Disturbances in the wound healing process after chlorhexidine use—a case report.] ZWR 1981 90(9) 68-70. 

In the wound healing process, infection also plays an important role. Aloe gel also exhibits antimicrobial, antifungal and anti-viral properties (S9). The inner gel of aloe exhibited antimicrobial activity against Shigella Jlexneri and... 

Fibrin is the major protein component of blood clots and is formed by enzymatic cleavage and polymerization of fibrinogen. Because of its important role in natural wound healing process, fibrin is an attractive functional material for tissue engineering. Additional... 

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