Cutaneous Wound Healing

Division of Piastic and Reconstructive Surgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Waies Hospitai, Hong Kong SAR, Peopie s Repubiic of China 

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Brown LF, Dubin D, Lavigne L et al (1993) Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound-healing. Am J Pathol 142(3) 793-801... 

Kane, C. J., Hebda, P. A., Mansbridge, J. N., and Hanawalt, P. C., Direct evidence for spatial and temporal regulation of transforming growth factor (31 expression during cutaneous wound healing, J. Cell Physiol., 148, 157, 1991. 

Woodley DT, O Keefe EJ and Prunieras M (1985). Cutaneous wound healing a model for cell-matrix interactions. J Am Acad Dermatol, 12, 420. 

I.-G. Rojas et al., Stress-induced susceptibility to bacterial infection during cutaneous wound healing, Brain, Behaviour and Immunity, 16, 2002, 74-84. 

Badiavas EV, Abedi M, Butmarc J, Falanga V, Quesenberry P. Participation of bone marrow derived cells in cutaneous wound healing. 

Jarvelainen H, Puolakkainen P, Pakkanen S, Brown EL, Hook M, lozzo RV, Sage EH, Wight TN. A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen 2006 14 443-452. 

These two reports 10 years apart reflect the continuing interest in heparin combinations playing a multifactorial role in wound healing. The role of heparin alone has also received considerable attention. Considerable research has looked at the role of heparin in anticoagulation but in the context of cutaneous wound healing the focus is on topical application. 

There is no doubt that carbohydrates play multiple and complex roles in the process of cutaneous wound healing. This chapter has been able to give only an overview of some of these roles and in many cases the mechanisms of action and effect are still in the process of being elucidated. 

GillitzerR, GoebelerM Chemokines in cutaneous wound healing. JLeukoc Biol 2001 69 513-521. Jones SA, Wolf M, Qin S, Mackay CR, Baggiolini M Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2. Proc Natl Acad Sci USA 1996 93 6682-6686. 

Sen, C.K., Khanna, S., Babior, B.M., Hunt, T.K., Ellison, E.C., and Roy, S., Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing, J. Biological Chem., 277, 33284-33290, 2002. 

Esimone CO, Nworu CS, Jackson CL (2008) Cutaneous wound healing activity of a herbal ointment containing the leaf extract of Jatropha curcas L. (Euphorbiaceae). Int J Appl Res Nat Prod 1 1-4... 

Baum CL, Arpey CJ. Normtil cutaneous wound healing cliniceil correlation with cellulttf and molecular events. Dermatol Surg. 2005 31 674-86. 

Intra-alveolar buds in OP are further characterized by prominent capUla-rization, which resembles granulation tissue in cutaneous wound healing (57). Vascular endothelial growth factor and basic fibroblast growth factor are widely expressed in intra-alveolar buds (58). Angiogenesis mediated by these growth factors could contribute to the reversal of buds in OP. 

Judith, R., Nithya, M., Rose, C., and Mandal, A. B. 2010. Application of a Pdgf-containing novel gel for cutaneous wound healing. Life Science, 87,1-8. 

Matsuda, H., Koyama, H., Sato, H., Sawada, J., Itakura, A., Tanaka, A., Matsumoto, M., Konno, K., Ushio, H., and Matsuda, K. 1998. Role of nerve growth factor in cutaneous wound healing Accelerating effects in normal and healing-impaired diabetic mice. Journal of Experimental Medicine, 187,297-306. 

Regenerative approaehes targeting dermal tissue elosely relate to cutaneous wound healing strategies (Section 7.5), and have special relevance for the treatment of chronie problems, such as those related to ulcers of various origin... 

Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341 738-746... 

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