Corneal epithelial wound healing

AJW Huang, SCG Tseng. (1991). Corneal epithelial wound healing in the absence of limbal epithelium. Invest Ophthalmol Vis Sci 32 96-105. 

Delayed corneal epithelial wound healing, PSC, decreased resistance to infection, decreased tear lysozyme, eyelid and conjunctiva hyperemia/edema/angioneurotic edema, subconjunctival hemorrhage, translucent blue sclera, increased lOP, myopia, exophthalmos, intracranial hypertension causing papilledema, diplopia, EOM paresis and eyelid ptosis, retinal hemorrhages (secondary to injection), central serous choroidopathy, abnormal ERGA EP, retinal embolic phenomenon (injection). 

Nutritional vitamin A deficiency causes xerophthalmia, a progressive disease characterized by night blindness, xerosis (dryness), and keratomalacia (comeal thinning), which may lead to perforation xerophthalmia may be reversed with vitamin A therapy. However, rapid, irreversible blindness ensues once the cornea perforates. Vitamin A also is involved in epithelial differentiation and may have some role in corneal epithelial wound healing. There is no evidence to support using topical vitamin A for keratoconjunctivitis sicca in the absence of a nutritional deficiency. 

Nakamura M, Sato N, Chikama TI, Hasegawa Y, Nishida T. Hyaluronan facilitates corneal epithelial wound healing in diabetic rats. Exp Eye Res 1997 64 1043-1050. 

Dale, P.D., Maini, P.K., and Sherratt, J.A., Mathematical modeling of corneal epithelial wound healing. Math. Biosci, 1994,124 127-147. 

Effect of Topical Fluconazole on Corneal Epithelial Wound Healing... 

Dabin, I. and Courtois, Y., 1991, Acidic fibroblast growth factor overexpression in corneal epithelial wound healing, Growth Factors, 5 129. 

Dastgheib KA, Clinch TE, Manche EE, Hersh P, Ramsey J. Sloughing of corneal epithelium and wound healing complications associated with laser in situ keratomileusis in patients with epithelial basement membrane dystrophy. Am J Ophthalmol 130 297-303 (2000). 

Saika, S., Uenoyama, K., Hiroi, K., Tanioka, H., Takase, K., andHikita, M., 1993, Ascorbic acid ester and wound healing in rabbit corneal alkali bums Epithelial basement membrane and stroma, Graefe s Arch. Clin. Exp. Ophthalmol. 231 221-227. 

While pain after photorefractive keratectomy needs to be treated effectively, the non-prescribed long-term misuse of local anesthetics can lead to impaired wound healing. Postulated mechanisms include inhibition of corneal epithelial migration and adhesion and toxic effects on stromal keratocytes [49 , 50 ]. 

Tissue repair is a very important process in eye irritation, particularly corneal lesions, but has rarely been studied. Epithelial migration and proliferation are the primary events occurring after epithelial injury. It has been shown that fibronectin stimulates epithelial cell migration, whereas hyaluronic acid is more active on proliferation (Salonen et aL, 1991 Inoue and Katakami, 1993). Growth factors (EGF, FGF, etc.) have also been shown to play a role in corneal epithelial and endothelial wound healing (Dabin and Courtois, 1991 Raphael et al. 1993 Hoppenreijs et al., 1994). The effects of chemicals on the synthesis of these components by corneal cells could be extremely important in the modulation of repair processes. 

Inflammation processes of cornea may cause persistent corneal defects and ulcers. In spite of different modem methods of treatment, these processes may result in development of cornea destmction with the following rough opacities in the cornea (Krasnov M.M., 1988). Healing of comeal epithelial defects depends on both appropriate effective treatment and common state of patient. One of a state of patient, which may result in different eye diseases (especially to traumatic wounds), is alcohol intoxication. This factor may explain the well-known fact that the most part of complications with... 

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