Angiogenesis wound healing

EGF — Angiogenesis, wound healing, proliferation/ differentiation of basal epithelial cells — Epithelial cells... 

While the role of PHD inhibitors in the treatment of anemia is now validated, therapeutic validation is less certain in other HIF-associated pathologies such as wound healing, ulcerative colitis, therapeutic angiogenesis, and treatment of acute ischemic events such as myocardial ischemia and stroke. All of these indications are supported by a compelling array of in vitro and in vivo preclinical studies but their utility in the clinical setting remains to be evaluated and represents exciting possibilities for the future of small-molecule inhibitors of PHD enzymes. 

Gorbet, M., Eckhaus, A., Lawson-Smith, R., May, M., Sefton, M., and Skarja, G., Material-induced angiogenesis in impaired wound healing. Wound healing Society Abstract, May 2003. 

Recently, the activities of host defense peptides related to the resolution of infection have been suggested to result in part from nondirect antimicrobial activities. It has been postulated that immunomodulation may represent the primary action of these peptides in vivo as the immunomodulatory activities are retained under physiological conditions in contrast to the direct antimicrobial activities of most natural mammalian host defense peptides. These immunomodulatory activities include, but are not limited to, direct chemotactic activity, induction of chemokines and other immune mediators, stimulation of leukocyte degranulation and other microbicidal activities, effects on leukocyte and epithelial cell survival and apoptosis, stimulation of epithelial and endothelial cell proliferation, promotion of wound healing and angiogenesis, antiendotoxic and anti-inflammatory activities, and adjuvant fiinctions. These will be described in detail in the following sections and a summary is found in Table 1. 

The technology of Low Level Laser Therapy (LLLT) was introduced into clinical medicine more than three decades ago. This form of treatment has great appeal due to its novelty, ease in use, relatively cost-efficient and low morbidity profile [5], LLLT has been shown to improve remarkably the process of wound healing in humans [5-8] and animal models [9-11], In vitro studies demonstrated that LLLT has a stimulating effect on cell mitosis [12] and proliferation and migration of fibroblasts [13], keratinocytes [14, 15] and endothelial cells [16], LLLT enhances NO secretion [17] and cytokine production [18, 19] and may lead to increased dermal angiogenesis [20],... 

Fibrinogen is a fibrous protein that was first classified with keratin, myosin, and epidermin based on its 5.1 A repeat in wide-angle X-ray diffraction patterns (Bailey et al., 1943), which was later discovered to be associated with the Q-helical coiled-coil structure. It is a glycoprotein normally present in human blood plasma at a concentration of about 2.5 g/L and is essential for hemostasis, wound healing, inflammation, angiogenesis, and other biological functions. It is a soluble macromolecule, but forms a clot or insoluble gel on conversion to fibrin by the action of the... 

---