Nitric oxide wound healing

Kudo FA, Warycha B, Juran PJ, Asada H, Teso D, Aziz F (2005) Differential responsiveness of early- and late-passage endothehal cells to shear stress. Am J Surg 190(5) 763-769 Lee RH, Efron D, Tantry U, Barbul A (2001) Nitric oxide in the healing wound a time-course study. J Surg Res 101(1) 104-108... 

Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing. J. Biol. Chem. 267, 21277-21280. 

In practice, some anticoagulation agents such as heparin or antiplatelet agents, e.g. nitric oxide (NO) are delivered to sensor sites in order to reduce the risk of thrombus formation. Nitric oxide (NO), which is a potent inhibitor of platelet adhesion and activation as well as a promoter of wound healing in tissue, has been incorporated in various polymer metrics including PVC (poly(vinyl-chloride)), PDMS (poly-dimethyl-siloxane) and PU (poly-urethanes). Those NO release polymers have been tested in animals as outer protection coatings and have shown promising effects for the analytical response characteristics of the sensor devices [137],... 

Knowing that nitric oxide and hyaluronic acid both play an important role in the wound healing process, Di Meo et al. chose to combine the properties of both entities and synthesized new NO-donors based on hyaluronic acid derivatives exhibiting a controlled NO-release under physiological conditions (in vitro tests). These derivatives were fully characterized by and 13C NMR spectroscopy and their NO release monitored by means of UV spectrophotometric measurements.47... 

Arginine Arginine is a precursor for a number of compounds, including proline and nitric oxide. Nitric oxide is a signalling molecule, proline is needed for formation of collagen, some of which is needed for provision of new tissue. Arginine has been shown to be benehcial for the healing of wounds and for this reason is included in some parenteral feeds (Table 18.4). 

Reichner JS, Meszaros AJ, Louis CA, Henry WL, Mastrofrancesco B, Martin BA, Albina JE. Molecular and metabobc evidence for the restricted expression of inducible nitric oxide synthase in healing wounds. American Journal of Pathology 1999, 154, 1097-1104. 

Mani, H., Sidhu, G.S., Kumari, R., Gaddipati, J.P., Seth, P., and Maheshwari, R.K., Curcumin differentially regulates TGF-betal, its receptors and nitric oxide synthase during impaired wound healing. Biofactors, 16 (1-2), 29 3, 2002. 

Luo, J.D., Chen, A.F. Nitric oxide a newly discovered function on wound healing. Acta Pharmacologica Sinica 26(3), 259-264 (2005)... 

Shekhter, A.B., et al. Beneficial effect of gaseous nitric oxide on the healing of skin wounds. Nitric Oxide-Biology and Chemistry 12(4), 210-219 (2005)... 

Soneja, A., Drews, M., Malinski, T. Role of nitric oxide, nitroxidative and oxidative stress in wound healing. Pharmacological Reports 57, 108-119 (2005)... 

Blecher, K., Martinez, L.R., Tuckman-Vernon, C., Nacharaju, R, Schairer, D., Chouake, J., Friedman, J.M., Alfieri, A., Guha, C., Nosanchuk, J.D., 2012. Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice. Nanomedicine Nanotechnology, Biology and Medicine 8,1364—1371. 

Lowe, A., Bills, J., Verma, R., Lavery, L., Davis, K., BaUcus, K., 2015. Electrospun nitric oxide releasing bandage with enhanced wound healing. Acta Biomaterialia 13, 121-130. 

Luo, J.-D., Wang, Y.-Y, Fu, W.-L., Wu, J., Chen, A.F., 2004. Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation 110, 2484—2493. 

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